间充质干细胞对自身免疫性干眼的免疫调控作用研究进展  

Recent advances in immune regulation of mesenchymal stem cells on autoimmune dry eye

作　　者：王希莲 路晓晓 杨丽媛[2] 粘红[2] 魏瑞华[2] 

机构地区：[1]天津北辰医院眼科,天津市300400 [2]天津医科大学眼科医院眼视光学院,天津市300384

出　　处：《眼科新进展》2017年第5期480-483,共4页Recent Advances in Ophthalmology

基　　金：国家自然科学基金资助(编号:81100646);天津市科委自然科学基金资助(编号:11JCYBJC26000;13JCYBJC23300);教育部留学回国人员科研启动基金资助项目(第48批);天津市北辰区科技发展计划项目(编号:BC2014-10)~~

摘　　要：间充质干细胞(mesonchymal stem cells,MSCs)具有良好的免疫调节功能,可以抑制多种免疫细胞群增殖,直接作用抑制T淋巴细胞的活化增殖,上调Treg细胞或通过分泌可溶性因子调节Th1/Th2反应平衡而发挥免疫调节作用,通过抗炎、调控各类性细胞因子的表达等方面抑制炎性因子的分泌同时促进抑炎因子分泌,降低基质金属蛋白酶2(MMP-2)、MMP-9等可能促进泪腺组织损害因子的表达水平,进而发挥其免疫调节作用,MSCs能减轻自身免疫性干眼的临床指标,恢复部分泪腺组织的分泌功能,本文就MSCs对自身免疫性干眼免疫调控的研究进展进行综述。Mesenchymal stem cells （MSCs） have good immune regulatory function, can inhibit many immune cell proliferation, direct effects on activation and proliferation of T cell, play a role in immune regulation by Treg cells or by the secretion of soluble factors regulating Th1/Th2 secretion and reaction equilibrium,inhibit the inflammation through the anti-inflammatory,regulation of cytoldnes expression at the same time, so reduce the expression levels of matrix metalloproteinase-2 and -9, which may pro- mote lacrimal gland tissue damage, and thus play a role in immune regulation. MSCs can reduce the autoimmune dry eye clinical index, recovery secretion function of part lacrimal gland. This article reviews the research advances in immune regulation of MSCs on autoimmune dry eye.

关 键 词：间充质干细胞 自身免疫性干眼 免疫调节 

分 类 号：R777.3[医药卫生—眼科]