中药益气养阴复方定心胶囊的质量工艺研究  

Exploration on Quality Technology of Dingxin Capsule for Supplementing Qi and Nourishing Yin

作　　者：曲颂扬[1] 田淼[2] 张艳[1] 毛清雯 朱爱松[1] 王辰[1] 

机构地区：[1]辽宁中医药大学附属医院,辽宁沈阳110032 [2]辽宁中医药大学,辽宁沈阳110847

出　　处：《中华中医药学刊》2017年第5期1265-1267,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：辽宁省医学高峰建设项目(2010061)

摘　　要：目的:探究定心胶囊质量工艺测定的研究方法。方法:以高效液相色谱法检测人参皂苷Rg1在中药益气养阴复方定心胶囊中的含量并通过薄层色谱鉴别法对处方中的丹参,黄芪和酸枣仁三位药材进行检测鉴别。结果:在薄层色谱中可检出丹参,黄芪和酸枣仁的特征斑点。人参皂苷Rg1在2.156~10.078μg范围内线性关系良好,r=0.999 7,精密度RSD=1.90%(n=5),重复性试验RSD=1.29%(n=5),其平均加样回收率为97.37%(RSD=1.90%,n=5)。结论:该方法准确性高,便于重复,易于操作,适合用于定心胶囊的质量检测。Objective：To establish the quality control method of Dingxin Capsule. Methods：TLC was used to distin- guish spina date seed, Tanshinone and Radix Astragali in the prescription. HPLC was used to determine the content of panaxoside Rgl in Dingxin Capsule. Result ： In TLC, the characteristic spots of salvia miltiorrhiza, Astragalus and semen zizyphi spinosae can be detected. The panaxoside Rgl had good relationship in the range of 2. 156 - 10.78 μg, r =0.999 7, precision RSD = 1.90% （n = 5） , repeated experiment RSD = 1.29% （n = 5）. The average recovery was 97.37% （RSD = 1.90% , n = 5）. Conclusion： The method is simple, accurate, reproducible and highly specific. It can control the quality of Dingxin Capsule.

关 键 词：定心胶囊 薄层色谱法 RG1 高效液相色谱法 

分 类 号：R284.1[医药卫生—中药学]