信号转导及转录激活因子1通路在肿瘤中的研究进展  

Research Progress of Signal Transduction and Activator of Transcription 1 Pathway in Tumor

作　　者：彭丽红 王康[2] 

机构地区：[1]南京同仁医院有限公司病理科,南京211102 [2]包头医学院研究生院,内蒙古包头014030

出　　处：《医学综述》2017年第9期1737-1741,1746,共6页Medical Recapitulate

摘　　要：信号转导及转录激活因子1(STAT1)被干扰素及其他信号分子激活,进而移入胞核活化其靶基因的转录。STAT1通路激活主要介导抗病毒防御及肿瘤抑制功能,同时它在肿瘤调控方面也可能发挥着抑癌基因的功能。但STAT1通路激活后亦能赋予肿瘤细胞对抗DNA损伤及促进肿瘤生长、侵袭的能力,故认为它是一种具有致癌作用的基因。因此,对Janus激酶/STAT1抑制剂和特异性作用于STAT1蛋白多肽类抑制剂的研究,将提供一种新的肿瘤靶向杀伤策略。Signal transduction and activator of transcription 1 （ STAT1 ） is activated by interferons and other signaling molecnles. Following activation, STAT1 is transferred into the nuclei and activates transcription of specific target genes. STAT1 pathway activation mainly mediates anti-viral defense and tumor suppression function, and it may also play a role as tumor suppressor genes. But it is also considered as an oncogene, since the activation of STAT1 pathway confers cellular resistance to DNA damage and promotes tumor growth and invasion. Therefore, recent researches in Janus kinase/STAT1 inhibitors and peptide inhibitors specific for STAT1 proteins may provide us with a new tumor targeted killing strategy.

关 键 词：肿瘤 信号转导及转录激活因子1 靶向杀伤 

分 类 号：R73[医药卫生—肿瘤]