胃癌STAT3、Survivin和RegⅣ的表达及其与临床病理参数间的相关性  

Expressions of STAT3,Survivin and RegⅣ and their correlations with clinicopathological features of gastric cancer

作　　者：何永亮[1] 王琦玲[1] 成永莲 欧阳海英[1] HE Yong-liang WANG Qi-ling CHENG Yong-lian OUYANG Hai-ying(Deyang Second People＇s Hospital, Oeyang 618000, China)

机构地区：[1]德阳市第二人民医院,四川德阳618000

出　　处：《现代医学》2017年第2期224-229,共6页Modern Medical Journal

摘　　要：目的:探讨胃癌中STAT3、Survivin和RegⅣ的表达及其与临床病理参数间的相关性,为临床治疗提供合理依据。方法:选取2013年1月至2015年1月本院采集的经病理学证实并接受手术切除治疗的70例胃癌组织石蜡标本,另取70例胃癌癌旁组织,配对30例正常胃组织;采用免疫组化染色法检测胃癌组织、癌旁组织以及正常胃黏膜组织标本中STAT3、Survivin及RegⅣ的表达水平,分析STAT3、Survivin及RegⅣ的表达与胃癌患者临床病理参数之间关系。结果:STAT3、Survivin及RegⅣ在胃癌组织中的阳性表达率明显高于胃癌旁组织和胃正常黏膜组织,差异均具有统计学意义(P<0.01)。STAT3、Survivin及RegⅣ在癌旁组织阳性表达率高于正常组织,但差异无统计学意义(P>0.05)。患者年龄、性别、肿瘤大小与胃癌组织中STAT3、Survivin及RegⅣ蛋白的表达均无关(P>0.05),而肿瘤细胞分化程度、浸润深度、淋巴结转移及肿瘤TNM分期与胃癌组织中STAT3、Survivin及RegⅣ蛋白的表达相关,差异均具有统计学意义(P<0.05)。当肿瘤细胞分化程度较低、浸润深度较深、伴有淋巴结转移、TNM分期较晚时,胃癌组织中的STAT3、Survivin及RegⅣ蛋白的表达阳性率较高(P<0.05)。Spearman等级相关性分析结果表明,STAT3、Survivin及RegⅣ呈正相关(P<0.01)。结论:肿瘤细胞分化程度较低、浸润较深、存在淋巴结转移及TNM分期较晚与胃癌组织中STAT3、Survivin及RegⅣ蛋白的表达呈正相关,且三者在胃癌组织中的表达均呈正相关,可能与胃癌的发生、侵袭、转移以及患者的不良预后存在密切联系。联合检测胃癌组织中三者表达情况有助于对胃癌恶性程度和患者的预后的临床判断并为基因靶向治疗提供理论依据。Objective： To explore the expressions of STAT3, Survivin and Reg 1V and their correlations with clinicopathological features of gastric cancer and provide a reference for instituting clinical treatment plan. Methods： 70 cases of gastric tissue specimens from January 2013 to January 2015,70 cases of the adjacent tissues and 30 cases of normal gastric mucosa were taken for SP immunohistochemical staining for detecting the expression of STAT3, Survivin and Reg IV in gastric cancer tissues, adjacent tissues, gastric mucosa tissues, and their correlations with patients＇ age, gender, tumor size, pathological differentiation, invasion and metastasis gastric cancer were analyzed. Results： STAT3, Survivin and Reg IV protein expression were gradually increased in turn of： normal tissues, adjacent tissues and carcinoma, the difference was significant （P 〈 0.05 ）. The positive rates of STAT3, Survivin and RegIV in the adjacent tissues were higher than those in normal tissues, but the difference was not significant （ P 〉 0.05 ） ; No significant associations were found either between STAT3, Survivin and Reg IV expression and patients＇ tumor size, age or gender （P 〉0.05）. The expression of STAT3, Survivin and RegIV in gastric cancer and the pathological differentiation, invasion depth, lymph node metastasis and TNM stage of gastric cancer were closely correlated （ P 〈 0.05 ）. Higher positive rate of STAT3, Survivin and Reg IV expression was found in a low degree of differentiation, more advanced invasion and lymph node metastasis, later TNM stages gastric cancer tissue （P 〈 0.05 ）. The expression of STAT3, Survivin and Reg IV in gastric cancer were positively correlated by the spearman rank correlation analysis （P 〈 0. 05 ）. Conclusion： The increased expessions of STAT3, Survivin and RegIV in gastric cancer are closely correlated with the pathological differentiation, invasion depth, lymph node metastasis and poor prognosis of gastric cancer. The detection of the expression of S

关 键 词：信号转导及转录活化因子 凋亡调控蛋白 再生基因Ⅳ 免疫组化 胃癌 

分 类 号：R735.2[医药卫生—肿瘤]