合并2型糖尿病乳腺癌患者的临床病理特征分析  

Clinicopathologic features of breast cancer patients with type 2 diabetes mellitus

作　　者：田晓菲[1] 李碧丽[2] TIAN Xiao-fei LI Bi-li(Department of General Surgery, the First Hospital of Handan, Handan 056002, China Gland Surgery, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China)

机构地区：[1]邯郸市第一医院普外科,河北邯郸056002 [2]内蒙古医科大学附属医院腺体外科,内蒙古呼和浩特010050

出　　处：《现代医学》2017年第2期239-243,共5页Modern Medical Journal

摘　　要：目的:分析乳腺癌合并2型糖尿病患者的临床病理学特征,为合并2型糖尿病乳腺癌患者的早期预防及个体化治疗提供临床指导。方法:收集内蒙古医科大学附属医院腺体外科2011年1月至2014年1月收治的最初确诊为原发性乳腺癌患者,其中合并2型糖尿病的乳腺癌患者共52例,设为病例组。按照1∶2的原则随机选取同期就诊于内蒙古医科大学附属医院腺体外科的非糖尿病乳腺癌患者共104例,设为对照组。排除男性乳腺癌患者、1型糖尿病及继发性糖尿病患者。比较两组临床病理学特征。结果:(1)原发性乳腺癌患者年龄24~86岁,平均51岁。其中共52例(4.9%)患有2型糖尿病,平均年龄(58.9±12.02)岁。(2)与对照组比较,病例组体质量指数较大(P<0.05)、临床分期较晚(P=0.001)、病理T分期较晚(P=0.007)、腋窝淋巴结转移率较高(P=0.036)。两组年龄,肿瘤的位置,恶性肿瘤家族史,糖尿病相关性疾病,绝经状况,组织学分级,组织学类型,ER、PR、Her-2、Ki67的表达差异均无统计学意义(P>0.05)。结论:(1)合并2型糖尿病乳腺癌患者体质量指数较高、临床分期及病理T分期较晚、腋窝淋巴结转移率较高。(2)糖尿病可能是乳腺癌发生发展和淋巴结转移的危险因素。Objective： To study the clinicopathologic features of breast cancer patients with type 2 diabetes mellitus for providing early prevention and individualized treatment for these patients. Methods： Through a case- control study of primary breast cancer patients initially diagnosed from January 2011 to January 2014 in The Affiliated Hospital of Inner Mongolia Medical University, 52cases of the breast cancer patients suffered Type 2 diabetes and 104 breast cancer patients without type 2 diabetes in the same period were selected were enrolled. The two groups of patients excluded the type 1 diabetes mellitus, the male patients and the secondary diabetes mellitus. Clinicopathologic features were compared between the case group and the control group. SPSS 13.0 statistical software was used for the analysis. Measurement data were expressed as mean ± standard deviation using t test; datacounting using chi- square test. Inspection standards, α 〈 0.05. Results ： （ 1 ） Of 1,052 primary breast cancer patients with the average age of 51, ranging from 24 to 86 years of age, 52 （4.9 % ） cases （with the average age of 58.9 ）suffered diabetes. （2） Compared with the control group, the case group had different clinicopathologicfeatures, with MBI （ P 〈 0.05 ）, clinical stage （ P = 0. 001 ）, pathological T stage （ P = 0. 007 ）, axillary lymph node metastasis （P = 0. 036）. No statistical significances （ P 〉 0.05 ） of age, pathological T stages, family history of malignancy, diabetes- related diseases, menopausal status, histological type, histological grade, or the expressions of estrogen receptor （ER）, progesterone receptor, human epidermal growth factor 2 （HER2） and Ki67 were found between the two groups. Conclusion： （1） Diabetes has a high incidence in breast cancer patients. （2） Breast cancer patients with type 2diabetes mellitus have a higher BMI, as well as higher clinical stage and pathological T stage and higher rate of axillary lymph node metastasis . （3） D

关 键 词：乳腺癌合并2型糖尿病 免疫组化 临床病理特征 

分 类 号：R737.9[医药卫生—肿瘤] R587.1[医药卫生—临床医学]