伯氏致病杆菌Xenorhabdus bovienii SN52中两个新的Rhabduscin类似物  

Two New Rhabduscin Analogues from Xenorhabdus bovienii SN52

作　　者：张文波[1] 石丹姝 张春珍[1] 于志国[1,2] 

机构地区：[1]沈阳农业大学植物保护学院,沈阳110866 [2]辽宁省生物农药工程技术研究中心,沈阳100866

出　　处：《有机化学》2017年第4期996-999,共4页Chinese Journal of Organic Chemistry

基　　金：辽宁省攀登学者2012资助项目~~

摘　　要：采用硅胶柱层析、凝胶柱层析和半制备高效液相色谱技术对伯氏致病杆菌Xenorhabdus bovienii SN52的次生代谢产物进行分离纯化,得到2个新的rhabduscin类似物.通过NMR和HR-ESI-MS等波谱技术和相关文献数据对照确定了它们的结构为4-O-(4-乙酰胺-β-L-鼠李糖苷)-苯甲醛(1)和4-O-(4-乙酰胺-β-L-鼠李糖苷)-(Z)-N-苯乙烯基甲酰胺(2).同时对化合物1和2的昆虫酚氧化酶抑制活性进行了评价.Two new rhabduscin analogues were isolated and purified from fermentation broth ofXenorhabdus bovienii SN52 by silica gel column chromatography, sephadex LH-20 chromatography and high performance preparative liquid chromatog- raphy. On the basis of spectroscopic methods （HR-ESIMS, 1D- and 2D-NMR） and by comparison with those reported previ- ously, their structures were identified as 4-O-（4-acetamide-β-L-rhamnoside）-benzaldehyde （1） and 4-O-（4-acetamide-β-L- rhamnoside）-（Z）-N-stvrvlforma mide （2）. Their inhibitory activities against Dhenoloxidase were also tested.

关 键 词：伯氏致病杆菌 rhabduscin类似物 结构鉴定 酚氧化酶活性 

分 类 号：Q936[生物学—微生物学] TQ920.1[轻工技术与工程—发酵工程]