6458例肺癌患者临床特征及诊疗现状分析  

Clinicopathological Features,Diagnoses and Treatments of 6458 Lung Cancer Patients

作　　者：李镭[1] 刘丹[1] 张立[2] 周萍[1] 宋娟[1] 程越[1] 余何[1] 赵爽[1] 李为民[1] 

机构地区：[1]四川大学华西医院呼吸与危重症医学科,成都610041 [2]四川大学华西医院病理研究室,成都610041

出　　处：《四川大学学报（医学版）》2017年第3期352-358,共7页Journal of Sichuan University(Medical Sciences)

基　　金：国家自然科学基金面上项目(No.81372504);国家自然科学基金-主任基金(No.81241068)和国家自然科学基金-青年基金项目(No.81201851)资助

摘　　要：目的归纳总结原发性肺癌患者的临床特点及流行病学特征,并了解其诊断、治疗现状。方法回顾性分析2008~2014年于四川大学华西医院确诊的6 458例原发性肺癌患者临床病理资料,分析病理分型与年龄、性别、TNM分期等临床特征的相关性,并归纳总结其诊断、治疗状况。结果 6 458例原发性肺癌患者中男4 291例、女2 167例;患者平均年龄为59.22岁,其中40岁以下者占5.1%(335例),50~70岁在各病理类型中均为高发年龄段,约占所有肺癌人群的61.1%;首诊时Ⅰ期患者仅10.5%(675例),绝大部分患者在首诊时即为Ⅳ期(53.3%)。最常见的病理类型为腺癌(3 523例,54.44%),其次为鳞癌(1 637例,25.35%)及小细胞肺癌(916例,14.18%)。在鳞癌、腺癌、小细胞癌及其他类型肺癌中,最主要的诊断方式均为纤支镜及手术等获取的标本进行病理学检查诊断;最主要的治疗手段为手术及化疗。结论近七年于我院就诊的原发性肺癌患者仍以中老年男性为主,腺癌居多;手术及纤支镜获取的标本进行病理学检查是最主要的诊断方式,而手术及化疗则是最主要的治疗手段。Objective Lung cancer is the leading cause of cancer-related death on a global scale. This study aimed to review the clinicopathological featuresof primary lung cancer and the practice in diagnoses and treatments. Methods Medical record of patients diagnosed with primary lung cancer in West China Hospital of Sichuan University from 2008 to 2014 were retrospectively reviewed. Clinical characteristics of the patients, including pathological type, age, gender, and TNM stage were analyzed. Results A total of 6 458 patients were diagnosed with primary lung cancer, with male patients comprising the majority （male： 66. 50%, n = 4 291 vs. female： 33.5%, n=2 167）. The patients had an average age of 59.22 yr. , mostly （61. 1%） between 50 and 70 yr. and 5.1% （n=335） under 40 yr.. More than hall （53. 3%） of the patients were at stage % at diagnosis, compared with 10.5%at stage I. The most common histological type was adenocarcinoma（ADC, n=3 523, 54. 44%）, followed by squamous cell carcinoma （SCC, n = 1 637, 25. 35%） and small cell lung cancer （SCLC, n = 916, 14. 18 M）. The majority of patients were confirmed with and chemotherapy. Conclusion Patients diagnosed with fibrobronchoscopy and surgery, and treated with surgery primary lung cancer in West China Hospital of Sichuan University are primarily elderly men. Adenocarcinoma is the main type. Fihrobronchoscopyis the main method for diagnosis, and chemotherapy and surgery are the main treatments for lung cancer.

关 键 词：肺癌 临床流行病学 病理类型 诊治现状 

分 类 号：R734.2[医药卫生—肿瘤]