调强适形放射治疗(IMRT)对鼻咽癌患者泪液分泌及视网膜黄斑厚度的影响  

Effect of Intensity Modulated Radiation Therapy on Tear Secretion and Macular Thickness in Patients with Nasopharyngeal Carcinoma

作　　者：张定富[1] 吴秋芳[1] 戈长征[1] 徐炎华[1] Zhang Ding-fu Wu Qiu-fang Ge Chang-zheng et al.(Department of Oncology,Jingzhou Central Hospital, Hubei,Jingzhou 434020, Chin)

机构地区：[1]湖北省荆州市中心医院肿瘤科,荆州434020

出　　处：《中国医药导刊》2017年第4期334-335,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:探讨调强适形放疗(IMRT)对鼻咽癌患者泪液分泌、视网膜黄斑厚度的影响作用。方法:选取本院肿瘤防治中心2009年至2012年收治的84例鼻咽癌患者进行分析,所有患者均在本院接受IMRT治疗,观察IMRT对鼻咽癌患者的泪液分泌及视网膜黄斑厚度的影响。结果:根据鼻咽癌患者的临床分期进行分层分析,结果显示在治疗前、治疗结束、治疗后3个月Ⅰ+Ⅱ期与Ⅲ+Ⅳ期鼻咽癌患者的泪膜破裂时间(BUT)、泪液中乳铁蛋白含量、泪液分泌量、视网膜黄斑厚度测定值差异均无统计学意义(P>0.05)。结论:IMRT对鼻咽癌患者泪液分泌、视网膜黄斑厚度均有不同程度的影响,并且与鼻咽癌患者的临床分期无关。Objective： To investigate the intensity-modulated radiotherapy （IMRT） effect on tear secretion and macular thickness in pa-tients with nasopharyngeal carcinoma. Metliods： Selected hospital cancer center from 2009 to 2012 were treated 84 patients with nasopha-ryngeal carcinoma were analyzed, all patients receiving IMRT treatment in hospital, observed IMRT impact on tear secretion and retinal macular thickness in patients with nasopharyngeal carcinoma. Results ： Stratified according to the clinical staging of NPC patients, it showed before treatment , end of treatment , after 3 months of treatment Ⅰ ＋ Ⅱ stage and Ⅲ ＋Ⅳ stage NPC patients BUT , tear lactofsecretion,macular thickness measured values were not significantly different （P 〉 0. 05）. Conclusion： IiMRT for pageal carcinoma tear secretion,have varying degrees of influence macular thickness, and is independent of the clinical staging of patients with nasopharyngeal carcinoma.

关 键 词：调强适形放疗 鼻咽癌 泪液分泌 视网膜黄斑厚度 

分 类 号：R739.63[医药卫生—肿瘤] R779.6[医药卫生—临床医学]