肺癌诊断中血清巨噬细胞抑制因子-1浓度检测的临床价值  

Clinical Value of Serum Macrophage Inhibitory Factor-1 in Diagnosis of Lung Cancer

作　　者：贾敬好[1] 王静[1] 杨海芳[1] 姚学敏[1] 王志武[1] 

机构地区：[1]河北省唐山市人民医院放化六科,唐山063001

出　　处：《中国医药导刊》2017年第4期415-416,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:探讨肺癌诊断中检测血清巨噬细胞抑制因子-1(MIC-1)的临床应用价值。方法:选取2009年6月~2015年12月于笔者所在医院就诊的肺癌患者360例为观察组,另随机选取同时期124例健康者为对照组。采用双抗夹心ELISA法检测两组患者血清MIC-1浓度,并检测血清癌胚抗原(CEA)、糖链抗原125(CA125)及神经元特异性稀醇化酶(NSE)。对比研究检测结果。结果:对照组患者血清中MIC-1及CEA、CA125、NSE浓度低于观察组,差异均有统计学意义(P<0.05)。结论:MIC-1可以作为肺癌诊断中较为理想的肿瘤标志物。Objective： To investigate the clinical application value of serum macrophage inhibitory falung cancer Methods： 330 cases of lung cancer in our hospital from June 2209 to December 2015 were selected as the observation group, then the same period 124 cases of healthy persons were selected as the control group randomly. Using double antibody sandwich ELISA meth-od for detection of two groups of patients with serum MIC-1 concentrations and detection of serum CEA, CA125 and NSE, the detection results were compared and analyzed. Results： The serum levels of MIC-1,CEA, NSE and CA125 in the control group were significantly those in the observation group, the difference was statistically significant （all P 〈0. 05）. Conclusion： MIC-1 camarker in the diagnosis of lung cancer.

关 键 词：肺癌 巨噬细胞抑制因子-1 肿瘤标志物 

分 类 号：R734.2[医药卫生—肿瘤]