荧光原位杂交检测胃腺癌中YAP基因的状态  

The clinical significance of fluorescence in situ hybridization on YAP gene in gastric cancer

作　　者：陈慧[1,2] 余波[1] 殷于磊[1] 肖立[1] 王葳 王华 李瑶[2] 陈燕[1] 

机构地区：[1]上海复旦大学附属华东医院病理科,上海200040 [2]上海复旦大学生命科学学院,上海201203 [3]上海市医疗器械检测所,上海201318

出　　处：《现代肿瘤医学》2017年第12期1949-1953,共5页Journal of Modern Oncology

摘　　要：目的:探讨胃腺癌中YAP基因的状态及其与临床病理特征、预后的相关性。方法:用分子荧光原位杂交技术检测人胃腺癌组织中YAP基因改变情况,并探讨YAP基因与患者的临床病理特征及预后的相关性。结果:13.5%(13/96)的胃腺癌中存在YAP基因拷贝数的增加,YAP基因拷贝数的增加与胃腺癌的不良预后显著相关(P=0.04)。结论:部分胃腺癌中存在YAP基因拷贝数增加且与不良预后相关。分子荧光原位杂交对YAP基因的检测有望为胃癌组织的早期诊断、预防、临床治疗和预后判断提供新的靶点和可靠依据。Objective： To investigate the correlation of YAP gene in gastric cancer and its clinical significance and prognosis. Methods： The YAP DNA expression in human gastric ductal adenocarcinoma tissues were detected by FISH and explored the relationship between clinical significance and prognosis of patients with YAP gene statue. Results：The positive rate of YAP gene in gastric carcinoma was 13. 5%（ 13/96）. The poor prognosis of gastric adenocarcinoma was significantly related to the increase of the copy number of YAP gene（ P = 0. 04）. Conclusion： The increase of the copy mumber of YAP gene in gastric adenocarcinoma was associated with a poor prognosis. Detection of YAP gene by FISH is expected to provide a new target and reliable basis for early diagnosis,prevention,clinical treatment and prognosis of gastric cancer.

关 键 词：胃腺癌 YAP基因 分子荧光原位杂交 预后 

分 类 号：R735.2[医药卫生—肿瘤]