2003—2012年食管癌高发区河北磁县上消化道癌发病率及年龄特点分析  

Analysis of the incidence and age characteristics of upper gastrointestinal cancer among 2003-2012 in the high incidence area of esophageal cancer,Cixian County, in Hebei Province

作　　者：宋国慧 马箐[2] 马山蕊 陈超 魏文强[2] 

机构地区：[1]邯郸市磁县肿瘤防治研究所肿瘤医院,056500 [2] 国家癌症中心/中国医学科学院北京协和医学院肿瘤医院

出　　处：《中华预防医学杂志》2017年第5期398-402,共5页Chinese Journal of Preventive Medicine

摘　　要：目的 探讨中国食管癌高发区磁县上消化道癌整体发病情况及年龄分布特点,为上消化道癌的防治工作提供依据.方法 收集2003—2012年河北省磁县肿瘤登记处逐年登记的肿瘤发病资料,截取食管癌和胃癌的所有发病病例数据.依据2000年全国普查标准人口构成计算中国人口结构标化发病率（中标率）,采用Segi＆#39;s的1964年世界标准人口年龄构成计算世界人口结构标化发病率（世标率）.用率的变化百分比（PC）来评价期末两年相对于期初两年的增长率;通过JoinPoint回归模型计算年度变化百分率（APC）.把10年资料分为前后两个时段（即2003—2007年和2008—2012年）,计算不同年龄组发病率率差.结果 2003—2012年上消化道癌发病率为165.36/10万（10309/6234346）,由2003年的170.75/10万（1029/602638）下降至2012年的146.02/10万（936/640991）,上消化道癌发病率的PC为-12.96%,APC为-1.54%（95%CI：-3.22%-0.07%）;中标率的PC为-10.83%,中标率的APC为-1.30%（95%CI：2.54%-0.03%）;世标率的PC为-9.82%,世标率的APC为-1.13%（95%CI：-2.20%--0.03%）,上消化道癌发病率整体呈下降趋势.2003—2007、2008—2012年发病率分别为171.55/10万（5239/3048593）、159.41/10万（5070/3180514）,发病率率差为-12.15/10万;70-74岁年龄组发病率下降最快,发病率率差为-340.32/10万,而85岁及以上年龄组发病率上升最快,发病率率差为447.21/10万.结论 2003—2012年磁县上消化道癌发病率呈下降趋势,下降率差最高的为70-74岁年龄组.Objective To investigate the overall incidence and age distribution of upper digestive tract cancer in Cixian county, and to provide a reliable basis of prevention and treatment for upper gastrointestinal cancer. Methods Collected annual incidence rate among 2003-2012 from Cixian cancer registry and abstracted all incidence rate of upper digestive tract cancer. The age-standardized incidence rate by Chinese standard population （ASR China） was calculated using the national population composition of 2000. The age-standardized incidence rate by world standard population （ASR world） was calculated using the world population composition of 1964 of Segi＆#39;s. The annual average change （APC） was used to estimate the growth rate of the last two years in comparision with the first two years, which was calculated by Joinpoint regression model. The data was divided into two sections （from 2003 to 2007, and from 2008 to 2012）, and the rate difference of different age group was calculated. Results The crude incidence rate of the digestive tract cancer from 2003 to 2012 was 165.36/100000 （10309/6234346）, which dropped from 170.75/10100000 （1029/602638） of 2003 to 146.02/100000 of 2012 （936/640991）.The PC and APC of the crude incidence rate of upper gastrointestinal cancer were-12.96%, and-1.54%（95%CI：-3.22%-0.07%）, respectively. The PC and APC of ASR China were-10.83%, and-1.30%（95%CI：2.54%-0.03%）, respectively. The PC and APC of ASR world were-9.82%, and-1.13%（95%CI：-2.20%--0.03%）, respectively. The incidence of upper gastrointestinal cancer decreased. The incidence rate of 2003-2007 and 2008-2012 were 171.55/100000 （5239/3048593）, and 159.41/10000 （5070/3180514）, respectively and the rate difference was -12.15/100000. The decrease of rate difference of 70 to 74 years old was the most （-340.32/100000） and the increase of rate difference over the age of 85 was the most （447.21/100000）. Conclusion From 2003 to 2012, the crude incidence of upper digestive tract can

关 键 词：食管肿瘤 胃肿瘤 发病率 上消化道癌 年度变化百分比 

分 类 号：R735.1[医药卫生—肿瘤]