氟比洛芬酯联合吗啡镇痛对胃癌根治术患者术后吗啡用药量及肠功能恢复的影响  

Effect of analgesia with flurbiprofen axetil and morphine on postoperative morphine dosage and intestinal function recovery in gastric cancer patients undergoing radical mastectomy

作　　者：覃鲁 张维恭 钟海生 

机构地区：[1]佛山市南海区第八人民医院麻醉科,广东佛山528200

出　　处：《海南医学》2017年第8期1258-1260,共3页Hainan Medical Journal

摘　　要：目的探讨氟比洛芬酯联合吗啡镇痛对胃癌根治术患者术后吗啡用药量及肠功能恢复的影响。方法选择我院2015年6月至2016年10月期间收治的56例胃癌根治术患者为研究对象,按随机数字表法分为两组,每组28例,对照组予常规硬膜外吗啡自控镇痛泵镇痛,观察组在此基础上应用氟比洛芬酯,比较两组患者术后疼痛视觉模拟评分(VAS)、吗啡用量及肠功能恢复情况。结果两组患者术后28 h及48 h的VAS评分比较差异均无统计学意义(P>0.05);术后28 h及48 h,观察组患者的吗啡用量分别为(40.36±14.65)mg和(60.64±14.45)mg,均明显少于对照组的(51.29±20.68)mg和(72.38±18.36)mg,差异均有统计学意义(P<0.05);观察组患者术后肛门排气时间为(48.19±11.14)h,明显短于对照组的(55.27±13.37)h,术后恶心呕吐发生率为10.71%,明显低于对照组的32.14%,差异均有统计学意义(P<0.05)。结论氟比洛芬酯与吗啡联合应用于胃癌根治术患者镇痛可发挥协同作用,进而减少吗啡的用量及胃肠道不良反应,促进术后肠功能的恢复。Objective To investigate the effects of analgesia with flurbiprofen axetil and morphine on post- operative morphine dosage and intestinal function recovery in gastric cancer patients undergoing radical mastectomy. Methods Fifty-six patients with radical gastrectomy in the Eighth People＇s Hospital of Nanhai District of Foshan from June 2015 to October 2016 were studied, which were randomly divided into two groups, 28 cases in each group. The patients in the control group were treated with routine morphine analgesia pump, and the patients in the observation group were treated with flurbiprofen axctil on basis of that treatment in control group. Postoperative pain visual analogue scale （VAS）, morphine consumption and intestinal function recovery between the two groups were compared. Results There was no significant difference in VAS between the two groups at 28 h and 48 h after operation （P〉0.05）. Morphine dosage at postoperative 28 h and 48 h in the observation group was （40.36±14.65） mg and （60.64± 14.45） mg, respectively, which were significantly less than （51.29±20.68） mg and （72.38±18.36） mg in the control group （P〈0.05）. The time of postoperative anal exhaust in the observation group were （48.19± 11.14） h, which was significantly shorter than （55.27 ± 13.37） h in control group. The incidence of postoperative nausea and vomiting were 10.71%, which was significantly lower than 32.14% in the control group （P〈0.05）. Conclusion Flurbiprofen axetil combined with morphine has a synergistic effect on analgesia in radical gastrectomy. It can reduce the dosage of morphine and the adverse reaction of gastrointestinal tract, and promote the recovery of postoperative intestinal function.

关 键 词：胃癌 胃癌根治术 氟比洛芬酯 吗啡 镇痛 

分 类 号：R735.2[医药卫生—肿瘤]