替加环素致急性胰腺炎  

Acute pancreatitis induced by tigecycline

作　　者：吴泽扬[1] 周晓明[2] 谷秀[2] 陈愉[2] 肇丽梅[3] 赵立[1] 

机构地区：[1]中国医科大学附属盛京医院急诊科,沈阳110004 [2]中国医科大学附属盛京医院呼吸内科,沈阳110004 [3]中国医科大学附属盛京医院药学部,沈阳110004

出　　处：《药物不良反应杂志》2017年第2期132-133,共2页Adverse Drug Reactions Journal

摘　　要：1例60岁男性败血症患者静脉滴注替加环素（首剂100 mg,此后50 mg,1次/12 h）累计10 d后出现腹胀、腹痛、左下腹压痛,实验室检查示WBC 18.4×10 9/L,中性粒细胞0.90,血清淀粉酶432 U/L,脂酶879 U/L,尿淀粉酶389 U/L.腹部CT示腹盆腔积液和十二指肠及胃周围有渗出.考虑为替加环素所致急性胰腺炎.嘱患者禁食水,留置胃管持续胃肠减压,停用替加环素并给予抑酸、抑制胰液分泌、静脉补液等对症处理.6 d后患者腹部症状消失,血清淀粉酶95 U/L、脂酶222 U/L,尿淀粉酶93 U/L.A 60-year-old man with septicemia received an IV infusion of tigecycline （first 100 mg, then 50 mg every 12 hours）.The patient developed abdominal distension, pain, and tenderness at left lower abdomen on the tenth day of cumulative medication.Laboratory tests showed the following values： white blood cell （WBC） 18.4×10 9/L, neutrophile granulocyte 0.90, serum amylase 432 U/L, lipase 432 U/L, urinea amylase 389 U/L.The result of abdominal CT showed effusion in abdominal pelvis, exudation around duodenum and stomach.The patient was diagnosed as acute pancreatitis induced by tigecycline.The patient was told to fast.He accepted gastrointestinal decompression by indwelling gastric tube.Tigecycline was withdrawn.He received symptomatic treatments including acid suppression, inhibition of pancreatic secretion, and intravenous infusion.Six days after symptomatic treatment, the patient＆#39;s abdominal symptoms were disappeared.Laboratory test showed the following values： serum amylase 95 U/L, lipase 222 U/L, urinea amylase 93 U/L.

关 键 词：胰腺炎 替加环素 

分 类 号：R576[医药卫生—消化系统]