体液微小RNA在胆管癌诊断中的研究进展  

Research progress on body fluids microRNAs in the diagnosis of cholangiocarcinoma

作　　者：邹荣基 马庆久[1] 

机构地区：[1]西安医学院研究生处,710021

出　　处：《国际肿瘤学杂志》2017年第4期300-303,共4页Journal of International Oncology

摘　　要：胆管癌发展慢但转移性极高,被发现时往往已错过最佳手术期,目前缺乏有效的诊断指标.近年来,随着分子生物学的飞速发展,研究发现微小RNA与胆管癌关系密切.由于微小RNA在各种类型的体液中有很大的稳定性,所以血清/血浆及胆汁中的微小RNA均有望成为胆管癌诊断中的潜在生物标志物.The development of cholangiocarcinoma is slow, but its metastasis is extremely quick.When the tumor is found, the patients often have missed optimal operation period, and there is a lack of effective diagnostic indexes at present.In recent years, with the rapid development of molecular biology, studies find that microRNAs （miRNAs） are closely associated with cholangiocarcinoma.Because of miRNAs have great stability in various types of body fluids, so miRNAs in serum/plasma and bile are expected to become potential biomarkers in the diagnosis of cholangiocarcinoma.

关 键 词：胆管肿瘤 血清 血浆 胆汁 诊断 

分 类 号：R735.8[医药卫生—肿瘤]