靶向瞬时受体电位通道天然调节剂的研究进展  

Natural modulators of transient receptor potential channels

作　　者：曹南开 吕海宁[1] 卫宁宁 李军[1] 屠鹏飞[1] 王克威[2] 姜勇[1] 

机构地区：[1]北京大学药学院,天然药物与仿生药物国家重点实验室,北京100191 [2]青岛大学药学院,山东青岛266021

出　　处：《药学学报》2017年第5期673-684,共12页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(81473106,81222051)

摘　　要：超家族瞬时受体电位(transient receptor potential,TRP)通道是存在于细胞膜上的非选择性阳离子通道,28个成员分为7个亚家族,广泛分布于人体的组织器官内,作为生物感受器参与调节视觉、听觉、味觉、痛觉和触觉等功能。到目前为止,从自然界中已发现TRP通道天然调节剂有100余种,来源于70余种动植物。本文系统综述了这些天然调节剂的来源、结构类型及其作用特点和机制,旨在为靶向TRP通道天然调节剂的发现及创新药物研究提供参考。Transient receptor potential （TRP） channels are non-selective and cation-permeable channels in the cell membrane, widely distributed in tissues and organs of human body. As biosensors, TRP channels can regulate the functions of vision, hearing, taste, pain, and touch, etc. So far, more than 100 different kinds of natural modulators targeting TRP channels have been identified from 70 species of plants or animals. In this review article, we attempt to summarize the effect of known natural active compounds on TRP channels with focuses on their sources, structures, action features and mechanisms. Hopefully this review can provide some useful information that can facilitate discovery of more specific natural modulators, and development of innovative therapeutic drugs targeting TRP channels.

关 键 词：瞬时受体电位通道 天然调节剂 TRPV TRPA TRPM TRPC 辣椒素 

分 类 号：R931.7[医药卫生—生药学] Q71[医药卫生—药学]