叶酸受体介导的宫颈上皮组织特殊染色在宫颈癌筛查中的应用  

Application of folate receptor-mediated cervical epithelial tissue specific staining in screening cervical cancer

作　　者：张春花[1] 吴玲[1] 杨慧[1] 杨洪波[1] 郁胜[1] 

机构地区：[1]淮安市妇幼保健院妇科,江苏省223002

出　　处：《江苏医药》2017年第8期570-572,共3页Jiangsu Medical Journal

摘　　要：目的探讨叶酸受体介导的宫颈上皮组织特殊染色(FRD)在宫颈癌筛查中的应用价值。方法对800例门诊患者行宫颈癌FRD筛查和人乳头状瘤病毒癌基因检测(HPV E6/E7);检出阳性患者行阴道镜检查和多点活检,以病理组织学检查作为金标准,比较两种检测方法的诊断效能。结果 180例患者接受了宫颈活检。FRD法的N/A病理符合率69.81%,高于HPV E6/E7法的41.51%(P<0.05);宫颈上皮内瘤变(CIN)2的病理符合率89.19%,高于HPV E6/E7法的67.57%(P<0.05)。在筛查CIN2及以上的病变中,FRD法的灵敏度与HPV E6/E7法相仿(88.76%vs.83.15%)(P>0.05),但FRD法的特异度优于HPV E6/E7法(57.14%vs.38.46%)(P<0.05)。结论在筛查CIN2及以上的病变中,FRD法的特异度优于HPV E6/E7法,且具有价格低廉和实时诊断的优点,适合用于宫颈癌的筛查。Objective To investigate the application value of folate receptor-mediated cervical epithelial tissue specific staining（FRD）in screening cervical cancer.Methods The screening for cervical cancer was carried out in 800 women using two methods of FRD and human papilloma virus testing for cervical cancer（HPV E6/E7）,of whom the patients with FRD or HPV E6/E7 positive received cervical biopsy via vaginoscopy.Taking pathological results as the golden standard,the diagnostic efficiency of FRD and HPV E6/E7 techniques was compared.Results The cervical biopsy was performed in 180 cases,and pathological coincidence rates for N/A and CIN2 were 69.81% and89.19% using FRD,which were higher than 41.51% and 67.57% using HPV E6/E7（P〈0.05）.For screening cervical lesions of CIN2 or higher,the sensitivity of FRD was similar to that of HPV E6/E7（88.76% vs.83.15%）（P〉0.05）,but the specificity of FRD was higher than that of HPV E6/E7（57.14% vs.38.46%）（P〈0.05）.Conclusion Compared to HPV E6/E7 method,FRD technique has the advantages of higher specificity,quicker diagnosis,less cost,and more suitable for screening the cervical lesions of CIN2 or higher.

关 键 词：叶酸受体介导的宫颈上皮组织特殊染色 人乳头状瘤病毒癌基因检测 宫颈癌 

分 类 号：R737[医药卫生—肿瘤]