高度近视患者黄斑区视网膜光敏感度的变化  

Retinal light sensitivity in different areas of the macula in high myopia

作　　者：吴秋艳[1] 陈绮[1] 谭凡[1] 程丹[1] 沈梅晓[1] 瞿佳[1] 

机构地区：[1]温州医科大学附属眼视光医院,325027

出　　处：《中华眼视光学与视觉科学杂志》2017年第3期146-151,共6页Chinese Journal Of Optometry Ophthalmology And Visual Science

基　　金：国家自然科学基金（81570880,81400441）;温州市公益性社会发展（医疗卫生）科技项目（Y20160151）

摘　　要：目的 通过微视野计测量比较高度近视患者与低度近视及正视者黄斑部各区域视网膜光敏感度的分布及差异.方法 描述性研究.选择2015年11月至2016年5月来温州医科大学附属眼视光医院视光门诊就诊的患者及在校学生志愿者共61例（61眼）,其中高度近视31例（31眼）作为高度近视组,低度近视及正视30例（30眼）作为对照组.通过微视野计测量黄斑区20＆#176;范围视网膜光敏感度,并按照早期糖尿病视网膜病变治疗研究进行3分环（中央区、内环、外环）和9分区（A1-A9）记录分析.采用独立样本t检验比较2组各区域的视网膜光敏感度差异,采用Pearson相关分析对视网膜光敏感度与眼轴长度（AL）的相关性进行分析.结果 高度近视组平均视网膜光敏感度较对照组低（t=4.60,P〈0.001）.3分环中,高度近视组在内环（t=3.30,P=0.002）和外环（t=3.63,P=0.001）视网膜光敏感度较对照组低.9分区中,高度近视组在A2（t=2.02,P=0.047）、A4（t=3.68,P=0.001）、A5（t=3.05,P=0.004）、A6（t=2.17,P=0.034）、A7（t=2.49,P=0.016）、A8（t=3.40,P=0.002）、A9（t=4.35,P〈0.001）区视网膜光敏感度较对照组低.黄斑区平均视网膜光敏感度与AL呈负相关（r=-0.477,P〈0.001）.结论 矫正视力正常的高度近视患者黄斑区视网膜光敏感度下降,且外环下降更明显.视网膜光敏感度的下降可能与AL的延长有关.Objective To investigate difference of retinal light sensitivity between high myopia subjects and low myopia to emmetropia subjects in the macular areas. Methods This descriptive study enrolled subjects from the Department of Optometry, Eye Hospital of Wenzhou Medical University, and campus volunteers, from November 2015 to May 2016. Clinical data were recorded and the subjects were divided into a high myopia group with 31 cases （31 eyes） and a control group with 30 cases （30 eyes）. Retinal light sensitivity was measured in the central 20＆#176; of the macula using a microperimeter. The macular area covered by the microperimeter was divided into three rings, including central, inner, and outer rings. The rings were further divided into nine areas （A1-A9）. Data in each area were compared by independent t-test between the two groups. The relationship between retinal light sensitivity and axial length was assessed by Pearson correlation analysis. Results The average retinal light sensitivity of the macula was reduced in the high myopia group compared to the control group （t=4.60, P〈0.001）. In the inner and outer rings, the retinal light sensitivity of the high myopia group was reduced （t=3.30, P=0.002; t=3.63, P=0.001 respectively）. For all three rings, the sensitivity was reduced in A2 （t=2.02, P=0.047）, A4 （t=3.68, P=0.001）,A5 （t=3.05, P=0.004）, A6 （t=2.17, P=0.034）, A7 （t=2.49, P=0.016）, A8 （t=3.40, P=0.002）, and A9 （t=4.35, P〈0.001）. Retinal sensitivity was inversely correlated with the axial length （r=-0.477, P〈0.001）. Conclusion Retinal sensitivity of the macular area was reduced in high myopia subjects with normal corrected visual acuity. The decreased sensitivity was more obvious in the outer ring and was correlated with increased axial length.

关 键 词：高度近视 黄斑区 视网膜光敏感度 微视野计 

分 类 号：R778.11[医药卫生—眼科]