p75NTR在胃癌组织中的表达及临床意义  

Expression and Clinical Significance of p75NTR in Gastric Cancer

作　　者：靳海峰[1] 赵敏 赵亮[3] 王力[4] 吴峥[5] 赵会懂[6] 侯会池[7] 朱焱华[8] 孙蓉[1] 姚欣[1] 吴晓云[1] 谷建芳[8] 

机构地区：[1]解放军白求恩国际和平医院消化内科,石家庄050082 [2]陆军参谋部门诊部,北京100042 [3]解放军白求恩国际和平医院心胸外科,石家庄050082 [4]解放军白求恩国际和平医院健康管理中心,石家庄050082 [5]河北医科大学第四医院生物治疗中心,石家庄050011 [6]解放军白求恩国际和平医院编辑部,石家庄050082 [7]解放军白求恩国际和平医院普通外科,石家庄050082 [8]解放军白求恩国际和平医院医务部,石家庄050082

出　　处：《临床误诊误治》2017年第5期94-97,共4页Clinical Misdiagnosis & Mistherapy

基　　金：全国优秀博士学位论文作者专项资金资助项目(201363)

摘　　要：目的探讨p75NTR在胃癌组织中的表达及临床意义。方法选择2015年1月—2016年1月在解放军白求恩国际和平医院行手术切除的胃癌60例,将其胃癌组织标本作为研究对象,根据患者淋巴结是否转移及病灶浸润深度进行分组。统计比较淋巴结转移阴性组、淋巴结转移阳性组以及病灶浸润肌层组、病灶浸润全层组p75NTR检测情况,并对淋巴结转移阴性组和淋巴结转移阳性组治疗后生活质量进行比较。结果淋巴结转移阴性组p75NTR检出阳性率显著高于淋巴结转移阳性组,两组比较差异有统计学意义(P<0.05)。病灶浸润肌层组p75NTR检出阳性率显著高于病灶浸润全层组,两组比较差异亦具有统计学意义(P<0.05)。治疗后淋巴结转移阴性组日常生活能力评分、躯体功能评分、心理功能评分及社会功能评分均显著高于淋巴结转移阳性组,两组比较差异均具有统计学意义(P<0.05)。结论 p75NTR水平检测可提示胃癌组织淋巴结转移情况以及病灶浸润深度,p75NTR水平检测可作为预测胃癌患者预后情况的依据。Objective To analyze the expression and clinical significance of p75NTR in gastric cancer. Methods A total of 60 samples of gastric cancer undergoing surgical resection of gastric cancer during January 2015 and January 2016 were selected as the study subjects. The content of the study in accordance with the medical ethics will be approved and for patients to understand, signed an informed consent. Retrospective analysis of clinical data of all patients. The positive rate of p75NTR in patients with lymph node metastasis negative group, positive group and the depth of invasion of the muscle layer group, all patients were detected, the positive rate was statistically analyzed. The quality of life was compared between lymph node me- tastasis positive group and negative group after chemotherapy. Results The positive rate of p75NTR in lymph node metastasis negative group was significantly higher than that in lymph node metastasis positive group, and the difference was statistically significant （ P 〈 0. 05 ）. The positive rate of p75NTRin infiltration depth of muscular layer was significantly higher than that of the depth of infiltration whole layer group, and the difference was statistically significant （ P 〈 0. 05 ）. After treatment, the rat- ing scales of viability, physical function, mental function and society function of lymph node metastasis negative patients were significantly higher than those of lymph node metastasis positive group, and the differences were statistically significant （P 〈 0.05）. Conclusion Expression of p75NTR in gastric carcinoma tissue can pretest cancerous tissue lymph node metastasis and invasion depth, and therefore clinical introduction of p75NTR index detection can basis as the effective prediction in prog- nosis of patients with gastric cancer.

关 键 词：胃肿瘤 P75NTR 基因表达 

分 类 号：R735.2[医药卫生—肿瘤]