葡聚糖微球联合多西紫杉醇介入治疗原发性肝癌的临床疗效  

The combination of sephedex and docetaxel used in intervention for clinical treatment of primary liver cancer

作　　者：李静娴[1] 姜艳萍[1] 王家平[2] 郭立[2] 朱黎[2] 柳瑞[2] 赵睿敏[2] 童玉云[2] 简远熙 

机构地区：[1]昆明医科大学校医院放射科,云南昆明650500 [2]昆明医科大学第二附属医院放射科,云南昆明650101

出　　处：《实用放射学杂志》2017年第5期739-741,753,共4页Journal of Practical Radiology

摘　　要：目的 研究葡聚糖微球联合多西紫杉醇碘化油混悬液运用于肝脏经导管动脉化疗栓塞术（TACE）治疗原发性肝癌的临床疗效.方法 将120例原发性肝癌患者随机分为实验组和对照组,每组各60例.实验组中的60例患者采用葡聚糖微球（Sephedex,G-50, 300～500 μm）联合多西紫杉醇碘化油混悬液行灌注化疗栓塞术,而对照组中的60例患者只采用多西紫杉醇碘化油混悬液行灌注化疗栓塞术.结果 2组插管手术成功率均为100%,术后平均随访12个月,观察2组患者术后12个月后的肿瘤最大直径缩小平均值实验组为（4.4±1.4） cm,对照组为（1.8±1.0） cm;治疗总缓解率实验组为70%,对照组为30%;甲胎蛋白（AFP）降低值实验组为（33.2±15.2） μg/L,对照组为（10.4±9.8） μg/L.结论 本研究创新性地在TACE术中运用葡聚糖微球联合多西紫杉醇碘化油混悬剂治疗原发性肝癌,并发现能显著提高疗效,因此该方法在临床推广运用中具有很大潜力.Objective To study the clinical efficacy of the combination of sephedex and docetaxel used in transcatheter arterial chemoembolization （TACE） for clinical treatment of primary liver cancer.Methods 120 patients with primary liver cancer in our hospital were divided into the experimental group and the control group randomly and equally, the 60 cases in experimental group were treated with sephedex suspensoid （Sephedex, G-50, 300-500 μm） and docetaxel-iodized oil, while other 60 cases in control group were treated with docetaxel-iodized oil suspension liquid.Results The success rate of surgical intubation in the two groups was 100%.After an average follow-up of 12 months, the postoperative tumor diameter of the experimental group was reduced by （4.4±1.4） cm, while that of the control group was （1.8±1.0） cm;The overall response rate was 70% in the experimental group in contrast to 30% in the control group;the alpha fetal protein （AFP） value was decreased by （33.2±15.2） μg/L in the experimental group and （10.4±9.8） μg/L in the control group.Conclusion The combination of sephedex, docetaxel suspensoid and iodized oil shows great potential in TACE treatment of primary liver cancer, from which the treatment effect can be improved significantly.

关 键 词：葡聚糖微球 多西紫杉醇 碘化油 原发性肝癌 经导管动脉化疗栓塞术 

分 类 号：R735.7[医药卫生—肿瘤] R815[医药卫生—临床医学]