兔急性少量蛛网膜下腔出血的模型建立及影像学表现  

Establishment of rabbit subarachnoid hemorrhage model and the imaging findings of a little amount of subarachnoid hemorrhage in acute phase

作　　者：黄亮[1] 李培岭[2] 翟昭华[3] 赵龙[4] 方向军[1] 

机构地区：[1]南华大学附属第二医院放射科,湖南衡阳421001 [2]河南省洛阳正骨医院影像中心,河南洛阳471002 [3]川北医学院附属医院放射科,四川南充637000 [4]川北医学院附属医院神经外科,四川南充637000

出　　处：《实用放射学杂志》2017年第5期777-780,787,共5页Journal of Practical Radiology

摘　　要：目的 拟通过动物实验,对比分析CT和MR常规序列对急性少量蛛网膜下腔出血（SAH）的诊断敏感度,以期发现更为敏感的检查方法.方法 选用新西兰大耳白兔18只,随机分为实验组（A组、B组）、对照组（C组）采用枕大池穿刺一次注血法建立SAH模型,分别于术后2 h、48 h行CT和MR扫描,记录CT和MR常规序列对SAH的显示.结果 ①实验组A组、B组MR FLAIR序列诊断兔急性少量SAH的敏感度较MR T1WI、T2WI及CT均高;MR FLAIR序列与CT比较,两者差异有统计学意义（P＜0.05）.②对照组C组未见SAH.结论 ①本研究成功建立了“枕大池一次注血法”兔SAH模型,为后续的影像学研究奠定了基础.②MR FLAIR序列对急性少量SAH的诊断较CT更为敏感,可常规用于急性少量SAH的诊断.Objective To explore the sensitivity of a little amount of subarachnoid hemorrhage （SAH） between CT and different MR sequences through animal experiment,to find a more sensitive way to diagnosis SAH.Methods 18 healthy adult white New Zealand rabbits were randomly divided into two experimental groups（group A and group B） and one control group（group C）.Rabbit SAH model was established by injecting blood into the cisterna magna one time.All rabbits underwent CT and MR scan at 2 hours,48 hours after operation.The findings on CT and different MR sequences were observed and recorded.Results ①In experimental groups（group A and group B）,MR FLAIR sequences in the diagnosis of a little amount of SAH was more sensitive than that on MR T1WI,T2WI and CT in acute phase.And the diagnosis sensitivity between MR FLAIR and CT was statistically significant（P〈0.05）.②Abnormal signs of SAH could not be found in group C.Conclusion ①Rabbit SAH model was established successfully which will be the foundation for the follow-up study of medical imaging.②MR FLAIR sequence is more sensitive to diagnose a little amount of SAH in acute phase,and may be used in the routine diagnosis of SAH in acute phase.

关 键 词：蛛网膜下腔出血 兔模型 计算机体层成像 磁共振成像 

分 类 号：R742[医药卫生—神经病学与精神病学] R332[医药卫生—临床医学]