肠易激综合征患者肠道中难辨梭状芽胞杆菌的变化  

The change of intestinal Clostridium difficile in patients with irritable bowel syndrome

作　　者：郑洁[1] 贾彦彬[1,2] 党彤[1] 

机构地区：[1]包头医学院第二附属医院内蒙古消化病研究所,内蒙古包头014030 [2]包头医学院基础医学与法医学院病原生物学教研室

出　　处：《胃肠病学和肝病学杂志》2017年第5期518-520,共3页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的观察肠易激综合征(irritable bowel syndrome,IBS)患者肠道中难辨梭状芽胞杆菌(Clostridium difficile,C.difficile)含量的变化,探讨IBS与C.difficile的相关性。方法根据罗马Ⅲ标准,收集包头医学院第二附属医院消化科收治的IBS患者30例,同时选取30名健康体检者作为对照组,利用实时荧光定量PCR方法检测研究对象粪便中C.difficile含量。结果与对照组比较,IBS患者及各亚型患者肠道C.difficile含量差异无统计学意义(P>0.05)。结论 IBS可能与C.difficile无相关性。Objective To observe the change of intestinal Clostridium difficile （C. difficile） in patients with irritable bowel syndrome （IBS） , and to investigate the correlation between IBS and C. difficile. Methods According to the Rome Ⅲ criteria, 30 patients diagnosed as IBS were recruited in the Department of Gastroenterology, the Second Affiliated Hospital of Baotou Medical College, and 30 health subjects were selected as control group. The contents of C. difficile in subjects＇ feces were measured by real-time quantitative PCR method. The contents of C. difficile between IBS and controls were compared. Results Compared with the control group, the contents of intestinal C. difficile in patients with IBS as well as in each subtype of IBS had no significant changes （P 〉 0.05）. Conclusion IBS may not be associated with C. difficile.

关 键 词：肠易激综合征 难辨梭状芽胞杆菌 实时荧光定量PCR 

分 类 号：R574.4[医药卫生—消化系统]