埃索美拉唑和替普瑞酮对功能性消化不良影响的对比研究  

Comparison of esomeprazole and teprenone on patients with functional dyspepsia

作　　者：赵卫东[1] 钟晓琴[1] 庄新英[1] 纪红梅[1] 李安庆[1] 李鑫鑫[1] 王瑞才[2] 朱建友[2] 李延青[3] 

机构地区：[1]滨州医学院附属临淄区人民医院消化内科,山东临淄255400 [2]滨州医学院附属临淄区人民医院病理科,山东临淄255400 [3]山东大学齐鲁医院消化内科

出　　处：《胃肠病学和肝病学杂志》2017年第5期521-525,共5页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的探讨埃索美拉唑和替普瑞酮对H.pylori阴性功能性消化不良(functional dyspepsia,FD)患者症状评分及胃肠道嗜酸粒细胞的影响。方法基线时对FD患者进行腹部症状问卷调查、胃镜检查、病理学检查、H.pylori检测。对H.pylori阴性者行埃索美拉唑或替普瑞酮治疗。第2周和第6周分别行腹部症状问卷调查,部分患者第6周末复查胃镜检查及病理学检查。结果第2周末时埃索美拉唑组和替普瑞酮组的症状均较基线时明显改善。第6周末时埃索美拉唑组症状评分较基线时也明显改善,但替普瑞酮组未见显著改变。第6周末时埃索美拉唑组较替普瑞酮组的症状显著减轻。治疗前后埃索美拉唑组与替普瑞酮组在胃十二指肠嗜酸性粒细胞计数及集簇率比较差异均无统计学意义(P>0.05)。结论埃索美拉唑对H.pylori阴性FD患者的治疗效果优于替普瑞酮。埃索美拉唑和替普瑞酮均不影响H.pylori阴性FD患者的胃十二指肠嗜酸性粒细胞计数及集簇率。Objective To investigate the influence of esomeprazole and teprenone on symptom scores and gastrointestinal eosinophils of H. pylori （ - ） functional dyspepsia （FD）. Methods Abdlominal symptoms questionnaire, gastroscopy, histologic examination and H. pylori detection were made according to baseline information. H. pylori-negative patients were enrolled in this study and randomly divided into two groups, treated with esomeprazole or teprenone seperately. The self-administered abdominal symptom questionnaire was used at 2nd week and 6th week, and part of the pa- tients underwent gastroscopy and pathology again at the end of 6th week. Results The symptom scores of both groups were all significantly different between 2nd week and baseline. The symptom scores of esomeprazole group were significantly different between 6th week and baseline, but those of teprenone group were not. The symptom scores were significantly different between esomeprazole group and teprenone group at 6th week. The eosinophil counts of duodenums and clustering rate in the esomeprazole group and teprenone group were all not statistically different before and after treat- ment. Conclusion The effect of esomeprazole is better than that of teprenone on H. pylori-negative FD patients. Neither esomeprazole nor teprenone show effect on the eosinophils level of stomach and duodenum in H. pylori-negative patients with FD.

关 键 词：功能性消化不良 嗜酸性粒细胞 幽门螺杆菌 药物疗法 

分 类 号：R57[医药卫生—消化系统]