复发性急性胰腺炎的临床特征分析  

Clinical survey of recurrent acute pancreatitis

作　　者：张菂[1] 刘亚萍[2] 张昊[1] 毕雅维 王丹[1] 郭洪雷[1] 曾祥鹏[1] 王腾[1] 辛磊[1] 胡良嗥[1] 徐茂锦[2] 李兆申[1] 

机构地区：[1]第二军医大学长海医院消化内科,上海200433 [2]第二军医大学长海医院内分泌科,上海200433

出　　处：《中华胰腺病杂志》2017年第2期88-92,共5页Chinese Journal of Pancreatology

基　　金：国家自然科学基金（81422010、81100316、81470883、81300355）;上海晨光计划（12CG40）;上海青年科技启明星计划（17QA1405500）;上海青年医生培养计划（AB83030002015034）;上海青年拔尖人才计划（HZW2016FZ67）

摘　　要：目的 探讨复发性急性胰腺炎（RAP）的临床特征.方法 收集和随访2016年1月至2016年7月间第二军医大学长海医院收治的RAP患者临床资料,并1∶1比例匹配慢性胰腺炎（CP）患者作为对照,建立前瞻性队列研究,分析比较两者临床特征的联系与差异.采用Kaplan-Meier法分析RAP从首次发病进展为CP的累计发病率.结果 100例RAP和100例CP患者中男性发病率分别为69.0%、60.4%（P=0.235）;平均发病年龄为38、21岁;青少年占比为12%、39%（P〈0.001）;糖尿病发生率为49.5%、9.0%（P〈0.001）;脂肪泻发生率为46.6%、19.0%（P〈0.001）.RAP进展为CP的1、3、5年累积发病率分别为2.0%、4.6%、12.4%.结论 RAP和CP均为男性发病率高于女性.与CP比较,RAP的首次发病年龄更晚,青少年发病率低,糖尿病和脂肪泻并发率低.Objective To analyze the clinical features of recurrent acute pancreatitis （RAP）.Methods The clinical data of patients diagnosed as RAP were collected in Changhai Hospital, the Second Military Medical University between January 2016 to July 2016, and chronic pancreatitis（CP） patients and RAP patients to matching, as control group.A prospective cohort study about the clinical features of RAP and CP was set.The survival analysis model was established by Kaplan-Meier′s method, to calculate the cumulative rate of RAP which progressed into CP.Results The morbidity of male patients was 69.0% in the RAP group（n=100） and 60% in the CP group（n=100）.The average first onset age of RAP and CP was 38 and 21 years old, respectively;and the teenagers accounted for 12% and 38.6%.The incidence of diabetes was 49.5% and 9%;and the incidence of fatty diarrhea was 46.6% and 19% of the two groups.The cumulative incidence of CP was 2% within 1 year, 4.6% in 3 years, and 12.4% in 5 years.Conclusions Men has higher morbidity in both RAP group and CP group.RAP patients′ first onset age was older than that of CP.Teenagers had a low incidence in RAP group.The risk of diabetes and fatty diarrhea was lower in RAP group than CP group.A certain proportion of RAP patients can progress to CP.

关 键 词：胰腺炎 慢性 复发性急性胰腺炎 疾病特征 

分 类 号：R576[医药卫生—消化系统]