循环肿瘤细胞与肿瘤转移机制的研究进展  

Research progress of circulating tumor cells and metastatic mechanism of tumor

作　　者：林健[1] 李恒宇[1] 吴凯男[1] 盛湲[1] 于跃[1] 

机构地区：[1]第二军医大学附属长海医院,上海200433

出　　处：《转化医学电子杂志》2017年第5期11-14,20,共5页E-Journal of Translational Medicine

基　　金：第二军医大学长海医院"1255"基金支持(CH125540800)

摘　　要：肿瘤转移是引起肿瘤患者死亡的主要原因.循环肿瘤细胞(CTCs)与肿瘤转移密切相关.本研究通过已有的文献,回顾分析有关CTCs的一系列转移过程:迁移渗入血液循环系统,适应外周循环系统并渗出至远端器官,突破免疫防御形成转移灶,了解其中涉及的可能影响肿瘤转移的诸多因素,例如毛细血管壁构成、组织微环境、细胞因子调节、细胞间相互作用及信号通路调节等.通过对这些文献的复习,能够帮助我们进一步了解肿瘤转移相关机制.Metastasis is the main cause of tumor death. Circulating tumor cells （CTCs） are closely related to tumor metastasis. In this paper, a series of metastatic process of CTCs were reviewed and analyzed： migrating into the circulating system, adapting to peripheral circulatory system, penetrating to distant organs, breaking through the immune defense and forming metastases. From the content mentioned above, we can understand several factors that may affect tumor metastasis, including constitution of blood capillary wall, tissue microenvironment , cytokine modulation, intercellular interaction and regulation of signal pathways. Through the review of literatures, we can further understand some mechanisms of tumor metastasis.

关 键 词：循环肿瘤细胞 肿瘤 转移 

分 类 号：R730.2[医药卫生—肿瘤] R730.7[医药卫生—临床医学]