磁朱丸联合阿立哌唑治疗精神分裂症患者疗效观察  

Observtion of Cizhu Pill Combined with Aripiprazole in the Treatment of Schizophrenia Patients

作　　者：田志林[1] 孙磊[1] 赵安全[1] 

机构地区：[1]唐山市第五医院,河北唐山063000

出　　处：《辽宁中医药大学学报》2017年第5期211-213,共3页Journal of Liaoning University of Traditional Chinese Medicine

摘　　要：目的:探讨磁朱丸联合阿立哌唑治疗精神分裂症患者的疗效观察。方法:根据随机数字表法将2013年1月—2016年2月我院收治的140例精神分裂症患者随机分为对照组(70例)与观察组(70例),对照组患者仅接受阿立哌唑治疗,观察组患者接受磁朱丸联合阿立哌唑治疗,现对比分析两组患者的疗效。结果:1治疗前后4个时间点之间简明精神病评定量表(BPRS)评分与阳性和阴性症状量表(PANSS)评分的比较:治疗前、治疗后2周、治疗后4周、治疗后8周等4个时间点之间观察组与对照组患者的BPRS评分、PANSS评分相比差异均有统计学意义(P<0.05),两组患者均以治疗前最高,治疗后2周次之,治疗后4周再次之,治疗后8周最低,各个时间点之间BPRS评分、PANSS评分比较相比差异均有统计学意义(P<0.05)。两组患者之间治疗前后4个时间点BPRS评分与PANSS评分比较:治疗前、治疗后2周、治疗后4周、治疗后8周,两组患者BPRS评分、PANSS评分比较差异均无统计学意义(P>0.05)。2采用不良反应量表(TESS)进行治疗安全性评价,两组患者失眠、心动过速、肝功能异常、静坐不能、心电图异常、嗜睡等不良反应发生率相比差异均无统计学意义(P>0.05),观察组震颤、视物模糊、恶心呕吐、肌强直、锥体外系反应显著低于对照组,差异有统计学意义(P<0.05)。结论:磁朱丸联合阿立哌唑治疗精神分裂症患者具有疗效确切、安全性好等优点。Objective： To observe effect of the Cizhu Pill combined with aripiprazole in the treatment of schizophrenia patients. Methods ： According to the random number table method, 140 cases of January 2013-2016 year in February in our hospital patients were randomly divided into split as the eontrol group （ 70 eases ） and observation group （ 70 cases ）, patients in the control group only received aripiprazole treatment, patients in the observation group received the Cizhu Pill combined with aripiprazole in the treatment, and comparative analysised, the effect of two groups of patients. Resuhs ： The treatment results between the 4 time points before and after the Brief Psychiatric Rating Scale （ BPRS ） score and the positive and negative symptom scale （ PANSS ） score were compared between before and after treatment, 2 W,4 W after treatment, after treatment of 8W 4 time points in the observation group and the control group of patients with BPRS score, PANSS the score had a significant difference （P〈0.05）, two groups of patients before treatment, after treatment with the highest, 2 W,4 W after treatment again after treatment, the lowest 8 W, each time point between the BPt/S score and PANSS score compared differences were statistically significant （ P〈0.05 ）. Between the two groups of patients before and after treatment of the 4 time points of BPRS score and PANSS score comparison ： before and after the treatment, 2 W, 4 W after treatment, 8 W after treatment, two groups of patients with BPRS score and PANSS score showed no significant difference （ P〉0.05 ）. The adverse reactions scale （ TESS ） for the treatment of safety assessment, two groups of patients with insomnia, taehycardia, abnormal liver function, akathisia, abnormal electrocardiogram, sleepiness and incidence of adverse reactions was no significant difference （ P〉0.05 ）, observation group tremor, blurred vision, nausea and vomiting, myotonia and extrapyramidal reactions was significantly lower than the control

关 键 词：磁朱丸 阿立哌唑 精神分裂症 

分 类 号：R749.3[医药卫生—神经病学与精神病学]