β淀粉样前体蛋白在难治性癫痫患者脑组织中的表达及其临床意义  

Expression of β-amyloid precursor protein in brain-tissue of patients with refractory epilepsy and its clinical significance

作　　者：马登飞 张建刚[1] 

机构地区：[1]安阳市人民医院,河南安阳455000

出　　处：《临床心身疾病杂志》2017年第2期5-6,10,共3页Journal of Clinical Psychosomatic Diseases

摘　　要：目的探讨β淀粉样前体蛋白在难治性癫痫患者脑组织病灶中的表达及临床意义。方法将32例难治性癫痫患者设为研究组，另选取因意外死亡需开颅的32例患者设为对照组，采用免疫组化检测脑组织中β淀粉样前体蛋白的表达。结果研究组可见病变处神经元丢失、变性、胶质细胞增生和轴突走向紊乱，可见大量棕黄色β淀粉样前体蛋白阳性细胞，在细胞胞浆和神经元轴突处均有沉积，阳性表达率为78．1％，对照组为15．6％，研究组阳性率显著高于对照组（P〈0．01）。结论β淀粉样前体蛋白在难治性癫痫脑组织中表达增高，导致癫痫反复发作，可能是难治性癫痫发病的重要原因之一。Objective To explore the expression of β-amyloid precursor protein （β-APP） in brain tissue of patients with refractory epilepsy （RE） and its clinical significance. Methods Thirty-two RE patients were assigned to research group and 32 accidental death ones who needed craniotomy to control group, the expression of β-APP in brain tissue was detected by immunohistochemistry. Results We found neuron loss, denaturalization, gliocyte proliferation and axon strike disturbance in lesion site as well as large quantities of brown-positive β-APP positive cells sedimentary in cell hyalomitome and neuron axon in research group, positive expression rate was respectively 78.1% in research and 15.6% in control group, and the former significantly higher than the latter （P〈0. 01）. Conclusion β-APP expression in brain tissue of RE patients increases, so that epilepsy recurrently attacks, which may be one of key causes of refractory epilepsy. [Keywords]

关 键 词：难治性癫痫 Β淀粉样前体蛋白 免疫组化检测 

分 类 号：R742.1[医药卫生—神经病学与精神病学]