氟西汀联合奥氮平治疗重度抑郁症伴自杀倾向患者对照研究  

Efficacy of fluoxetine combined with olanzapine in the treatment of major depression with suicidal tendency

作　　者：李艳艳[1] 张淑玲[1] 

机构地区：[1]郑州人民医院,河南郑州450000

出　　处：《临床心身疾病杂志》2017年第2期53-55,共3页Journal of Clinical Psychosomatic Diseases

摘　　要：目的探讨氟西汀联合奥氮平治疗重度抑郁症伴自杀倾向患者的临床疗效。方法将86例重度抑郁症伴自杀倾向患者采用随机数字表法分为观察组和对照组各43例，均给予氟西汀治疗，观察组联合奥氮平治疗，观察2个月。于治疗前后采用汉密顿焦虑量表与汉密顿抑郁量表评定两组患者的焦虑、抑郁情况。比较两组患者的治疗总有效率及不良反应发生率。结果观察组总有效率为90．7％，对照组为72．1％，观察组显著高于对照组（P〈0．05）。治疗后两组汉密顿焦虑量表与汉密顿抑郁量表评分均显著低于治疗前（P〈0．01），观察组较对照组下降更显著（P〈0．01）。观察组不良反应发生率为11．6％，对照组为9．3％，两组比较差异无显著性（P〉0．05）。结论氟西汀联合奥氮平治疗重度抑郁症伴自杀倾向患者效果较好，优于单用氟西汀治疗，安全性高，值得在临床推广应用。Objective To explore the efficacy of fluoxetine combined with olanzapine in the treatment of major depression （MD） with suicidal tendency （ST）. Methods Eighty-six MD patients with ST were assigned to observation and control group of 43 ones each according to random number table, both groups were treated with fluoxetine, and observation was plus olanzapine for 2 months. Anxious and depressive conditions were assessed with the Hamilton Anxiety Scale （HAMA） and Hamilton Depression Scale （HAMD） respectively. Total effective rates and the incidences of adverse reactions were compared between 2 groups. Results After treatment total effective rate was respectively 90.70 % in observation and 72.1% in control group and the former significantly higher than the latter （P〈0.05）. After treatment the HAMA and HAMD scores of both groups were significantly lower compared with pretreatment （P 〈0.01） and those lowered more significantly in observation than in control group （P〈0.01）. The incidence of adverse reaction was respectively 11.63% in research and 9.30% in control group, which showed no significant difference （P〈0.05）. Conclusion Fluoxetine combined with olanzapine have a better effect and higher safety compared with single fluoxetine in the treatment of MD patients with ST, which deserves clinical generalization and application.

关 键 词：氟西汀 奥氮平 重度抑郁症 自杀倾向 汉密顿焦虑量表 汉密顿抑郁量表 

分 类 号：R749.41[医药卫生—神经病学与精神病学]