奥氮平与利培酮治疗老年痴呆伴发精神障碍的疗效及安全性比较  

Comparison of Curative Effect and Safety of Olanzapine and Risperidone in the Treatment of Senile Dementia Combined with Mental Disorders

作　　者：李欣[1] 薛坤喜 吴勇 杜宝国 

机构地区：[1]中山市小榄人民医院心理科,广东中山528415 [2]中山市第三人民医院精神科,广东中山528400

出　　处：《临床医学工程》2017年第5期665-666,共2页Clinical Medicine & Engineering

摘　　要：目的比较奥氮平与利培酮治疗老年痴呆伴发精神障碍的疗效及安全性。方法选取我院2014年3月至2016年8月期间收治的100例老年痴呆伴发精神障碍患者,随机分为研究组与对照组,各50例。研究组采用奥氮平治疗,对照组采用利培酮治疗。分析比较两组患者的治疗效果和不良反应情况。结果治疗后,两组患者的总有效率比较差异无统计学意义(P>0.05)。研究组的阿尔茨海默行为病理评估量表(BEHAVE-AD)评分改善情况明显优于对照组(P<0.05)。研究组的不良反应发生率显著低于对照组(P<0.05)。结论应用奥氮平与利培酮治疗老年痴呆伴发精神障碍患者,均能够获得良好的疗效,但奥氮平具有更高的安全性和临床应用价值。Objective To compare the curative effect and safety of olanzapine and risperidone in the treatment of senile dementia complicated with mental disorders. Methods 100 cases of patients with senile dementia complicated with mental disorders admitted to our hospital from March 2014 to August 2016 were selected and randomly divided into study group and control group, with 50 cases in each group. The study group was treated with olanzapine, while the control group was treated with risperidone. The treatment effect and adverse reactions of patients were compared between two groups. Results After treatment, no statistical difference was found in the total effective rate between two groups （P 〉0.05）. The improvement of alzheimer＇s disease behavior pathological scale （BEHAVE-AD） score of study group was significantly better than that of control group （P 〈0.05）. The incidence of adverse reactions of study group was significantly lower than that of control group （P 〈0.05）. Conclusions Olanzapine and risperidone in the treatment of patients with senile dementia complicated with mental disorders have good curative effect, but olanzapine has higher safety and clinical application value.

关 键 词：老年痴呆 精神障碍 奥氮平 利培酮 

分 类 号：R749.16[医药卫生—神经病学与精神病学]