从纳米给药系统角度探讨阿尔茨海默病的治疗策略  

Strategies for treatment of Alzheimer's disease from the perspective of nano-drug delivery system

作　　者：王立[1] 梁爽[1] 吕江维[1] 薛冰[1] 张文君[1] 

机构地区：[1]哈尔滨商业大学药学院,黑龙江哈尔滨150076

出　　处：《药学研究》2017年第5期287-291,共5页Journal of Pharmaceutical Research

基　　金：2016年哈尔滨商业大学青年创新人才支持项目(No.2016QN075)

摘　　要：阿尔茨海默病严重威胁人类健康,主要是血脑屏障限制了药物到达作用靶点,影响阿尔茨海默病的治疗。而纳米给药系统为药物的脑靶向递送提供了可能,对阿尔茨海默病的治疗有改善作用,本文从阿尔茨海默病的发病机制和常规治疗药物展开,重点从纳米给药系统角度进行介绍阿尔茨海默病的治疗策略,概述几种典型的治疗阿尔茨海默病的纳米给药系统,即脂质体、聚合物胶束、固体脂质纳米粒和聚合物纳米粒等。Alzheimer＇s disease is a serious threat to human heahh,mainly blood brain barrier limits the drug to reach the target and affects the treatment of Alzheimer＇s disease.The nano-drug delivery system for brain-targeted drug delivery offers the potential treatment and improvement for Alzheimer＇s disease.This article started from the pathogenesis and con- ventional therapeutic drugs of Alzheimer＇s disease, focusing from nano-drug delivery systemperspective to introduce the treatment strategies of Alzheimer＇s disease and summarized several typical treatment strategies of Alzheimer＇s disease nano- drug delivery systems, namely,liposomes, polymer micelles, solid lipid nanoparticles and polymer nanoparticles.

关 键 词：阿尔茨海默病 纳米给药系统 脂质体 聚合物胶束 固体脂质纳米粒 聚合物纳米粒 

分 类 号：R749.16[医药卫生—神经病学与精神病学]