肺癌化疗患者院内感染病原菌及耐药性分析  

Analysis of the etiologic characteristics of nosocomial infections for patients with lung cancer treated chemotherapy

作　　者：郭阳[1] 孙玉玲[1] 王海英[1] 

机构地区：[1]首都医科大学附属北京世纪坛医院感染科,北京100038

出　　处：《中国实验诊断学》2017年第5期813-815,共3页Chinese Journal of Laboratory Diagnosis

摘　　要：目的分析肺癌化疗者医院感染的病原菌特点及耐药性情况。方法 2013年2月至2016年10月在我院接受化疗治疗的104例肺癌患者的临床资料,分析入选者的感染部位、感染病原菌及不同病原菌对抗菌药物的耐药性情况。结果出现医院感染的104例肺癌化疗者中,呼吸道感染者比例最高(56,53.8%)。共分离出110株感染病原菌,其中以革兰阴性菌为主(73株,66.4%),其次是革兰阳性菌(30株,27.3%),真菌(7株,6.4%)。革兰阴性菌对青霉素的耐药率最高(57株,78.1%),革兰阳性菌对青霉素G的耐药率最高(22株,73.3%),真菌对氟康唑耐药率最高(5株,71.4%)。结论了解行化疗治疗的肺癌医院感染者的病原菌及其耐药性特点,促进临床抗菌药物的合理使用,给临床诊断提供一定的理论依据。Objective Our retrospective study was aimed to analyze the etiologic characteristics of nosocomial infections for patients with lung cancer treated chemotherapy. Methods Clinical data of 104 patients with lung cancer received treatment of chemotherapy at our hospital from February, 2013 to October, 2016 was retrospectively analyzed. The infection site distribution,species susceptible to pathogens as well as their constituent ratio,and drug resistance of different pathogens to commonly used antibiotic was performed was analyzed. Results Among 104 patients with lung cancer received treatment of chemotherapy,the patients with respiratory tract infections accounted for 53.8% （56 cases）. A total of 110 strains pathogenic bacteria infection isolated, the major pathogens were the gram-negative bacteria （66.4 %）, followed by the gram-positive bacteria （27.3%） and fungus （6.4 % ）. The drug resistance rate of the gram- negative bacteria to penicillin was the highest （78.1% ）. The drug resistance rate of the gram-positive bacteria to peni- cillin G was the highest （73.3%）. The drug resistance rate of the fungus to flueonazole was the highest （71.4%）. Conclusion The understanding of the etiologic characteristics of nosocomial infections for patienLs with lung cancer treated chemotherapy can relatively low resistance for patients infected with different types of bacterial is of great clinical significance to effectively treat patients with pulmonary infections,promote clinically rational use of antibiotics,increase the efficiency of infection control, which offering certain theoretical basis for clinical diagnosis.

关 键 词：医院感染 化疗 肺癌 耐药性 病原菌 

分 类 号：R734.2[医药卫生—肿瘤]