奥替溴胺联合洛哌丁胺治疗腹泻型肠易激综合征的疗效及机制分析  

Efficacy of otilonium bromide combined with loperamide in the treatment of diarrhea type irritable bowel syndrome and mechanism analysis

作　　者：翁国武[1] 刘真义 

机构地区：[1]海南省第三人民医院消化科,海南三亚572000

出　　处：《安徽医药》2017年第1期143-146,共4页Anhui Medical and Pharmaceutical Journal

摘　　要：目的观察奥替溴胺联合洛哌丁胺治疗腹泻型肠易激综合征(IBS-D)的疗效及对血清水通道蛋白-3(AQP-3)和水通道蛋白-8(AQP-8)水平的影响。方法选择符合纳入标准的IBS-D病人共110例,按数字表法随机分为对照组和观察组,两组均55例;两组参照《肠易激综合征诊断和治疗的共识意见》给予非药物治疗;对照组给予奥替溴胺片,每次40 mg,每天3次,口服;观察组在对照组基础上给予洛哌丁胺,初始剂量2~4 mg,每天2次;两组病人均连续观察6周。比较两组腹痛、腹泻、腹胀评分及临床疗效;应用IBS生活质量问卷(IBS-QOL)量表评价两组生活质量;检测两组血清AQP-3和AQP-8水平。结果治疗后,观察组病人的腹胀、腹泻、腹痛评分均明显低于对照组(P<0.01);观察组病人治疗后总有效率为96.36%,显著高于对照组(83.02%)(P<0.05);观察组治疗后IBS-QOL量表评分均明显高于对照组(P<0.01);治疗后,观察组治疗后AQP-3和AQP-8水平明显高于对照组,差异有统计学意义(P<0.01)。结论奥替溴胺联合洛哌丁胺治疗IBS-D疗效明显,上调血清AQP-3和AQP-8水平可能是该疗法作用机制之一。Objective To investigate the efficacy of otilonium bromide combined with loperamide in the treatment of diarrhea type irri-table bowel syndrome （IBS-D） and the influence on serum levels of water channel protein 3（ AQP-3） and AQP-8. Methods One hun-dred and ten patients with IBS-D were randomly divided into control group and observation group with 55 cases in each group according to random number table. Both groups were treated with non-drug therapy according to a treatment plan of integrated Chinese and western medicine of irritable bowel syndrome＂. Control group orally received otilonium bromide（40 mg,tid）. Based on control group,observa- tion group was treated with loperamide（2 ～4 mg, b id ） . Treatment course was 6 weeks for all cases. Scores of abdominal pain, diarrhea, and abdominal distension and efficacy were compared between two groups. IBS-QOL scale was used to evaluate life quality. Serum levels of AQP-3 and AQP-8 were detected in both groups. Results Scores of abdominal pain, diarrhea, and abdominal distension were obvi-ously lower than those of control group after treatment（P 〈0. 01）. Clinical efficacy of treatment group was 96. 36 % , which was higher than that of control groups 83. 02 % （ P 〈0.05） . After treatment, scores of IBS-QOL and serum levels of AQP-3 and AQP-8 of observa-tion group were remarkably higher than that of control group （P 〈0.01） . Conclusion Efficacy of otilonium bromide combined with loperamide in the treatment of diarrhea type irritable bowel syndrome is obvious,and can up-regulate serum levels of AQP-3 and AQP-8.

关 键 词：奥替溴胺 洛哌丁胺 腹泻型肠易激综合征 水通道蛋白3 水通道蛋白8 

分 类 号：R574.4[医药卫生—消化系统]