以Nrf2为靶点防治肾脏疾病的研究进展  

Research on preventative role of Nrf2 in kidney diseases

作　　者：曹思思[1,2,3] 颜苗[2,3] 张毕奎[2,3] 蒋云生[4] 樊新荣[5] 

机构地区：[1]中南大学药学院,湖南长沙410011 [2]中南大学湘雅二医院药学部,湖南长沙410011 [3]中南大学临床药学研究所,湖南长沙410011 [4]中南大学湘雅二医院肾内科,湖南长沙410011 [5]中国中医科学院,北京100700

出　　处：《中国药理学通报》2017年第3期301-305,共5页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81202985;81573686;81373708)

摘　　要：核因子Nrf2是调控机体内源性抗氧化信号通路的核心转录因子,其调控一系列抗氧化酶、Ⅱ相解毒酶和Ⅲ相转运体的表达,维持机体氧化还原平衡。而且,Nrf2还能调控炎症反应。近年来,研究证实Nrf2在肾脏疾病的防治中具有重要生理学作用,激活Nrf2能提高细胞或组织的抗氧化应激和抗炎能力,减轻机体损伤。因此,该文综述了Nrf2对各种肾脏疾病的保护作用,探讨以Nrf2为靶点防治肾脏疾病的可能性。Nrf2,a key transcriptional factor in regulating endog-enous antioxidant signaling pathway,maintains the redox bal-ance by controlling the expression of a battery of antioxidant en-zymes,phase-Ⅱ detoxification enzymes and phase-Ⅲ transport-ers.Furthermore,Nrf2 regulates inflammation.Recent resear-ches have confirmed that Nrf2 provides a vital physiological role in kidney diseases,activation of Nrf2 enhances the antioxidant and anti-inflammatory ability in cellular and tissue levels,thusalleviates renal injury.Here,this article aims to summarize the protective effect of Nrf2 on various models of kidney impairment and explore the potential of Nrf2 as a therapeutic target to pre-vent kidney diseases.

关 键 词：NRF2 氧化应激 NF-κB 肾缺血/再灌注 急性肾毒性 慢性肾脏疾病 糖尿病肾病 

分 类 号：R-05[医药卫生] R322.61