急性脑梗死患者体内血小板CD62P和sTLT-1的表达水平  

The levels of CD62P and Soluble TREM-Like Transcript 1 in patients with acute cerebral infarction

作　　者：陆丽丽[1] 刘丹[1] 庞春燕[1] 张伟[1] 张广炜[1] 

机构地区：[1]内蒙古科技大学包头医学院第一附属医院神经内科,内蒙古包头014010

出　　处：《中风与神经疾病杂志》2017年第2期105-107,共3页Journal of Apoplexy and Nervous Diseases

基　　金：内蒙古科技大学包头医学院青苗计划项目(No.2016H0906)

摘　　要：目的大量研究表明血小板CD62P和sTLT-1能够促进动脉粥样硬化性血栓的形成,因此我们检测急性脑梗死患者体内血小板CD62P和sTLT-1的表达水平,以作为评价动脉粥样硬化性血栓形成的功能指标。方法选择急性脑梗死患者(发病时间≤7 d)102例作为病例组,同期选择来我科就诊的非急性脑梗死患者93例为对照组,采用流式细胞仪(flow cytometry,FCM)检测血小板CD62P的表达水平,用酶联免疫吸附法(enzyme linked immunosorbent assay,ELISA)检测血清中sTLT-1的表达水平。结果急性脑梗死组的血小板CD62P和sTLT-1的表达水平均明显高于对照组(P<0.01),CD62P和sTLT-1的表达水平与急性脑梗死患者的神经功能缺损程度及梗死灶体积呈正相关;CD62P和sTLT-1之间呈直线正相关(r=0.247,P<0.01);多元Logistic回归分析,CD62P和sTLT-1在校正其他相关危险因素后[CD62P(%)OR值=1.102,95%CI:1.062~1.143,P<0.01;sTLT-1(pg/ml)OR值=1.004,95%CI:1.002~1.006,P<0.01]。结论血小板CD62P和sTLT-1是脑梗死发病的危险因素,可能是急性脑梗死患者体内动脉粥样硬化性血栓形成的独立危险因素。Objective Recent studies suggest that the CD62P and soluble triggering receptor expressed on myeloid cells-like transcript 1 （ sTLT-1） facilitate atherothrombosis. Therefore, We evaluated CD62P and sTLT-1 as functional meas-ures of atherothrombosis in acute cerebral infarction （ ACI）. Methods The case group includes 102 patients with acute cerebral infarction from department of neurology （within the first 7 days after the onset of stroke） ,and the control group in-cludes 93 patients with non acute cerebral infarction. The level of CD62P was detected by flow cytometry, the level of sTLT- 1 was detected by enzyme linked immunosorbent assay. Results The level of CD62P and sTLT-1 were dramaticlly higher than the control group （ P 〈 0. 01） . They have obviously positive correlation between degree of neurofunction impairment and volume of infarction. CD62P and sTLT-1 are positive linear correlation（ r =0. 247, P 〈 0. 0 1 ） . Multivariate analysis showed that CD62P and sTLT-1 are independent indicators of acute cerebral infarction[ CD62P（ % ） OR = 1. 102 ,95% C/ ： 1.062 - 1. 143 yP 〈 0.01 ; sTLT-1 （pg/ml） OR = 1 .0 0 4 ,95% C l： 1 .002 - 1.006 〈 0 .01 ] . Conclusion Platelet activity markersCD62P and sTLT-1 are the risk factor of may be functional measures of acute cerebral infarction and may be independent predictors of atherothrombosis in acute cerebral infarction.

关 键 词：急性脑梗死 动脉粥样硬化性血栓形成 血小板 CD62P sTLT-1 

分 类 号：R743.3[医药卫生—神经病学与精神病学]