缺血性脑血管病患者血清RBP水平与颈动脉粥样硬化斑块的相关性研究  

Relationship of serum levels of RBP with carotid atherosclerotic plaque in ischemic cerebrovascular disease

作　　者：徐东升[1] 王引明[1] 殷晓菁[1] 胡玲玲[1] 孔亮[1] 

机构地区：[1]南通大学附属第三医院无锡市第三人民医院神经内科,江苏无锡214041

出　　处：《中风与神经疾病杂志》2017年第2期115-118,共4页Journal of Apoplexy and Nervous Diseases

摘　　要：目的探讨缺血性脑血管病(ICD)患者颈动脉粥样硬化性斑块与视黄醇结合蛋白(RBP)含量的关系。方法选取121例ICD患者和95例正常对照者,检测血清RBP水平;同时检测ICD组、对照组患者血清UA和血浆DD、FIB水平。对于ICD患者结合其颈动脉超声检查结果,又分为无斑块组(57例)、颈动脉稳定斑块组(32例)、颈动脉不稳定斑块组(32例);测定并比较各组血清RBP水平。结果 ICD组血清RBP水平显著高于正常对照组(P<0.05);在ICD患者中,颈动脉稳定斑块组、不稳定斑块组血清RBP水平较无斑块组有明显升高(均P<0.05);另外颈动脉不稳定斑块组血清RBP水平显著要高于稳定斑块组(P<0.05)。线性相关分析表明RBP水平与UA、DD、FIB水平无相关性(r=0.149、0.056、0.065,均P>0.05);Logistic回归分析结果显示:RBP是发生颈动脉粥样斑块的一个危险因素(OR=2.318,95%CI 0.007~0.721)。结论血清RBP可能与动脉粥样硬化发生、发展密切相关,并且可能与ICD患者动脉粥样硬化斑块的稳定性密切相关。Objective To discuss the relationship of serum levels of retinol-binding protein （ RBP） with carotid ath-erosclerotic plaque in ischemic cerebrovascular disease （ICD） . Methods The levels of the serum RBP,acid （U A ）an d the levels of plasma D-dimer（D-D） ,fibrinogen （FIB） were detected in 121 patients with ischemic cerebrovascular disease and 95 normal controls at the some time. Patients with ICD were divided into no plaque group （57 cases） , stable plaque group （32 cases） ,unstable plaque group （32 cases） according to their carotid artery sonography. The serum levels of RBP were determined and compared among different groups. Results Serum levels of RBP in patients with ICD were significantly in-creased than those of normal control subjects （ P 〈 0. 05 ）. Among patients with ICD, the serum levels of RBP in stable plaque group and unstable plaque group were significantly increased compared with no plaque group （ all P 〈0. 05） ,and A-mong patients with ICD,the serum levels of RBP in unstable plaque group were significantly increased compared with in sta-ble plaque group （P 〈0. 05） . Linear correlation analysis showed that serum levels of RBP was not correlated with those of UA, D-D and FIB （ r = 0. 149 ,0. 056 ,0. 065 ,all P 〉 0. 05 ） . Logistic regression shows that RBP are the risk factors of re-currence of carotid atherosclerotic plaque （ OR = 2 . 318 ,95% Cl 0. 007-0. 721） . Conclusions Serum RBP may be closely related to the occurrence and development of atherosclerosis. It could be associated with stability of atherosclerotic Plaques in patients with ICD.

关 键 词：缺血性脑血管病 颈动脉斑块 视黄醇结合蛋白 

分 类 号：R743.3[医药卫生—神经病学与精神病学]