血清胱抑素C对老年人脑萎缩的预测价值  

Diagnostic value of cystatin C in predictig cerebral atrophy in elderly people

作　　者：于诗嘉[1] 于明军[2] 冯娟[1] 

机构地区：[1]中国医科大学附属盛京医院神经内科,辽宁沈阳110004 [2]中国医科大学附属盛京医院神经外科,辽宁沈阳110004

出　　处：《中风与神经疾病杂志》2017年第2期145-147,共3页Journal of Apoplexy and Nervous Diseases

摘　　要：目的研究血清胱抑素C(CysC)与老年人脑萎缩疾病的关系,探讨血清CysC对疾病的预测价值。方法收集114例脑萎缩组与127例非脑萎缩组患者的临床、实验室及影像学资料,比较两组间各因素差异,Logistic回归分析独立危险因素。通过头部CT检查对脑萎缩组进行评估,分析血清Cys与脑萎缩严重程度的相关性。绘制血清CysC对老年人脑萎缩患病的ROC预测曲线。结果血清CysC是老年人脑萎缩的独立危险因素(P<0.05,OR值0.030,95%CI 0.007~0.124)。ROC曲线下面积为0.699(95%CI 0.634~0.765),最佳诊断界值为1.09 mmol/L。血清CysC与老年人脑萎缩严重程度呈正相关(r1=0.229,P1<0.05;r2=0.223,P2<0.05)。结论血清CysC与老年人脑萎缩发生和发展存在相关性,并存在一定预测价值。Objective To analyze the relationship between cystatin C and general cerebral atrophy in elderly people, and explore the diagnostic value of cystatin C in predicting general cerebral atrophy in elderly people. Methods We collected 114 persons as brain atrophy group and 127 persons as non-atrophy group, comparing the difference of each factor between two groups and using Logistic regression to determine the independent risk factors. Brain CT scans were used to es-timate the severity of disease. Then we studied the relationship between cystatin C and the progression of brain atrophy. Re-ceiver operator curve （ROC） was set up to detect the predictive value of cystatin C on general cerebral atrophy in elderly people. Results CysC was one of the independent risk factors of general cerebral atrophy in elderly people （P 〈 0 .0 5 ,OR =0. 030,95% CI 0. 007 - 0. 124） . The area under ROC curve by CysC was 0. 6 9 9 （9 5% CI 0. 634 - 0. 765 ） . The optimal threshold value for CysC was 1.09 mmol/L. CysC level was positively correlated with the disease progression （r1=0.229, P1 〈 0. 05 ; r2 = 0. 223 ,P2 〈 0.05 ） . Conclusion There is correlation between CysC and the development and progression of general cerebral atrophy in elderly people. Besides CysC has predictive value for the disease.

关 键 词：血清胱抑素C 老年人脑萎缩 头部CT 

分 类 号：R742[医药卫生—神经病学与精神病学]