肺腺癌组织HDAC1、HDAC5和E-cadherin表达及相关性研究  

The expression of HDAC1,HDAC5,E-cadherin and their correlation in lung adenocarcinoma tissue

作　　者：石威炯 郝吉庆[1] 

机构地区：[1]安徽医科大学第一附属医院肿瘤内科,合肥230022

出　　处：《临床肿瘤学杂志》2017年第4期309-313,共5页Chinese Clinical Oncology

摘　　要：目的检测组蛋白去乙酰化酶1(HDAC1)、组蛋白去乙酰化酶5(HDAC5)和上皮型钙粘蛋白(E-cadherin)在肺腺癌组织中的表达,并分析三者表达的相关性。方法采用免疫组化SP法检测93例肺腺癌组织和48例癌旁组织中HDAC1、HDAC5和E-cadherin的表达情况。分析三者表达与肺腺癌临床病理特征的关系,以及三者表达的相关性。结果肺腺癌组织中HDAC1的阳性表达率为58.06%,高于癌旁组织的20.83%,差异有统计学意义(P<0.05);癌旁组织中HDAC5和E-cadherin的阳性表达率分别为66.67%、68.75%,均高于肺腺癌组织的48.39%、45.16%,差异有统计学意义(P<0.05)。HDAC1和E-cadherin表达与年龄有关(P<0.05),E-cadherin表达还与分化程度有关(P<0.05);HDAC5表达与肺腺癌临床病理特征均无关(P>0.05)。HDAC1分别与HDAC5、E-cadherin表达呈负相关(r=-0.224、r=-0.236,P<0.05);HDAC5与E-cadherin表达无明显相关性(r=0.159,P>0.05)。结论在肺腺癌组织中联合检测HDAC1、HDAC5和E-cadherin可能对判断预后、合理选择药物有一定指导意义。Objective To detect the expression of histone deacetylase 1（ HDAC1）,HDAC5 and E-cadherin in lung adenocarcinoma tissue and analyze their correlation. Methods The expression of HDAC1,HDAC5 and E-cadherin in 93 cases of lung adenocarcinoma and 48 adjacent tissues was detected by immunohistochemical SP method. The relationship between the protein expression and clinicopathological characteristics,and the correlation among the three proteins were analyzed. Results The positive rate of HDAC1 expression in lung adenocarcinoma was 58. 06%,which was higher than that in adjacent tissues（ 20. 83%）,and the difference was statistically significant（ P 〈 0. 05）. The positive expression rates of HDAC5 and E-cadherin in the adjacent tissues were 66. 67%and 68. 75%,which were higher than those of lung adenocarcinoma tissues（ 48. 39% and 45. 16%）,and the difference was statistically significant（ P 〈 0. 05）. The expression of HDAC1 and E-cadherin was correlated with age（ P 〈 0. 05）,and the expression of Ecadherin was related to the degree of differentiation（ P 〈 0. 05）. The expression of HDAC5 was not correlated with clinicopathological characteristics（ P 〉 0. 05）. HDAC1 was negatively correlated with HDAC5 and E-cadherin（ r =-0. 224,r =-0. 236,P 〈 0. 05）.There was no significant correlation between HDAC5 and E-cadherin（ r = 0. 159,P 〉 0. 05）. Conclusion The expression of HDAC1,HDAC5 and E-cadherin in lung adenocarcinoma tissue suggested that there was a certain relationship among the three proteins,and the combined detection of the three proteins may be helpful to predict the prognosis and select the drug reasonably.

关 键 词：肺腺癌 组蛋白去乙酰化酶1(HDAC1) 组蛋白去乙酰化酶5(HDAC5) 上皮型钙粘蛋白(E-cadherin) 

分 类 号：R734.2[医药卫生—肿瘤]