基于试验序贯分析检验Cochrane泌尿外科学组Meta分析假阴性结果  

Examining the false-negative results of meta-analyses of Cochrane urology group using trial sequential analysis

作　　者：翁鸿 李晓东[4] 尹晓红[1,2,3] 宁向辉 赵宇航[6] 曾宪涛[1,2,3,7] 

机构地区：[1]武汉大学中南医院循证与转化医学中心 [2]武汉大学循证与转化医学中心 [3]武汉大学第二临床学院循证医学与临床流行病学教研室,武汉430071 [4]河南大学淮河医院泌尿外科,科研与研究生工作处,河南开封475000 [5]北京大学第一医院泌尿外科,北京100034 [6]武汉大学中南医院神经外科,武汉430071 [7]武汉大学中南医院泌尿外科,武汉430071

出　　处：《中国循证医学杂志》2017年第5期593-597,共5页Chinese Journal of Evidence-based Medicine

基　　金：国家重点研发计划专项基金(编号:2016YFC0106300)

摘　　要：目的采用试验序贯分析(TSA)检验Cochrane泌尿外科学组累积Meta分析假阴性结果。方法计算机检索The Cochrane Library(2016年6期)泌尿外科学小组的系统评价,查找具有阴性结果的Meta分析。由2位研究者独立进行文献筛选和资料提取,然后采用TSA 0.9β软件进行TSA。结果共纳入11篇文献,包括12个Meta分析。TSA结果显示,12个Meta分析中,有4个(33%)Meta分析的结论既未穿过TSA界值,也未达到期望信息量,为潜在的假阴性结果。结论 Cochrane泌尿外科学组Meta分析的部分阴性结果为假阴性,TSA可以辅助判断Meta分析的结果是否为假阴性结果。Objective To detect the false-negative results of cumulative meta-analyses of Cochrane Urology Group with the trial sequential analysis （TSA）. Methods The Urology Group of The Cochrane Library （Issue 6, 2016） was searched to collect meta-analyses with negative results. Two researchers independently screened literature and extracted data of included meta-analyses. Then, TSA was performed using TSA software version 0.9 beta. Results A total of 11 papers involving 12 meta-analyses were included. The results of TSA showed that, four （33%） out of 12 meta- analyses were potentially false-negative results for failing to surpass the trial sequential monitoring boundary and to reach the required information size. Conclusion Some of the negative results of systematic reviews from Cochrane Urology Group was false-negative. TSA can help researchers to identify the false-negative results ofmeta-analyses.

关 键 词：试验序贯分析 META分析 假阴性结果 COCHRANE系统评价 

分 类 号：R-03[医药卫生] R699