感染性角膜炎的病原菌谱回顾性分析  

A retrospective analysis of the pathogens associated with infectious keratitis

作　　者：徐红云[1] 陈弟[1] 刘海[1] 刘春林[1] 李红[1] 马众仙[1] 李宜铮[1] 杨宝瑞[1] 杨文波[1] 

机构地区：[1]云南省第二人民医院检验科,昆明650021

出　　处：《中国感染与化疗杂志》2017年第3期260-263,共4页Chinese Journal of Infection and Chemotherapy

摘　　要：目的分析感染性角膜炎的病原菌谱特征,提供感染性角膜炎早期诊断及治疗的依据。方法收集云南省第二人民医院眼科2011年1月至2015年12月,确诊为感染性角膜炎患者的角膜溃疡刮片或术中切除的角膜溃疡组织标本资料,对普通细菌及真菌培养的结果进行回顾性分析,评价感染病原菌谱的分布特征及危险因素。结果 1 046例(只眼)的角膜溃疡标本培养阳性率为35.3%。分离的病原菌以真菌为主(53.1%),其次是革兰阳性球菌(31.2%)、革兰阴性杆菌(11.1%)及革兰阳性杆菌(4.6%);而真菌中以镰刀霉属构成比最高,为69.4%,其次是曲霉属(21.9%);革兰阳性球菌以凝固酶阴性葡萄球菌为主(50.4%)。结论该院感染性角膜炎以真菌性角膜炎多见,主要病原菌是丝状真菌,以镰刀霉属的感染为主。Objective To study the pathogens associated with infectious keratitis for early diagnosis and treatment. Methods This study was conducted with the patients with confirmed diagnosis of infectious keratitis in our hospital during the period from January 2011 through December 2015. The specimens from corneal ulcer were subject to bacterial and fungal culture. The pathogens and associated risk factors of infectious keratitis were analyzed retrospectively. Results Of the 1 046 corneal specimens, 369 （35.3%） were positive for microorganisms. The most frequently isolated microorganism was fungal species （53.1%）, followed by gram- positive cocci （31.2%）, gram-negative bacilli （11.1%）, and gram-positive bacilli （4.6%）. Of the fungal strains, most were Fusariurn （69.4%）, followed by Aspergillus species （21.9%）. Coagulase negative Staphylococcus accounted for more than half （50.4%） of the gram positive cocci. Conclusions Infectious keratitis is primarily associated with fungal infection, especially filamentous fungus such as Fusariurn.

关 键 词：感染性角膜炎 病原菌 丝状真菌 分布特征 

分 类 号：R772.21[医药卫生—眼科]