高危子宫内膜癌术后调强放疗联合TC化疗的疗效观察  

Clinical Effect Observation of Intensity Modulated Radiotherapy Combined with TC Chemotherapy in the Treatment of High Risk Endometrial Cancer Operation

作　　者：李国强[1] 罗敬[1] 郑志坚[1] 徐玉云[1] 张锦宏[1] 陈爱辉[1] 杨海坤[1] 

机构地区：[1]广东省梅州市人民医院(中山大学附属梅州医院),广东梅州514000

出　　处：《中国医学创新》2017年第14期21-24,共4页Medical Innovation of China

基　　金：广东省梅州市科技计划项目(2015B013)

摘　　要：目的:分析高危子宫内膜癌术后治疗中,调强放疗联合紫杉醇+卡铂(TC)化疗治疗方案的应用效果。方法:应用随机数字表法,将80例已接受手术治疗的高危子宫内膜癌患者分为对照组和观察组,每组40例。对照组术后接受调强放疗,观察组术后接受调强放疗联合TC化疗。对比两组近期疗效及随访生存情况。结果:两组完成治疗并随访3个月时,均无患者死亡。入组时,两组各项FACT-G-V4评分比较,差异均无统计学意义(P>0.05),完成治疗并随访3个月时,观察组各项FACTG-V4评分均低于对照组(P<0.05)。治疗及随访期间,两组不良反应发生率比较,差异无统计学意义(P>0.05)。此外,截至2016年12月31日,观察组中位生存期明显优于对照组,差异有统计学意义(P<0.05)。结论:调强放疗联合TC化疗治疗方案可有效提高高危子宫内膜癌术后的生存质量。Objective： To analyze the application effect of intensity modulated radiotherapy combined with Paclitaxel ＋ Carboplatin （ TC ） chemotherapy in the treatment of high risk endometrial carcinoma after operation. Method： A total of 80 cases with high risk endometrial cancer who had received surgical treatment were divided into the control group and the observation group with 40 cases in each group according to random number table method.The control group was treated with intensity-modulated radiation therapy, while the observation group was treated with intensity-modulated radiotherapy combined with TC chemotherapy.Then, the short-term efficacy and follow-up survival of two groups were compared.Result： Two groups were treated and followed up for 3 months, and none of patients died.There were no statistical significance in FACT-G-V4 scores of two groups （ P〉0.05 ） . FACT-G-V4 scores of the observation group after treatment and follow-up for 3 months were lower than those of the control group （ P〈0.05 ） .During the course of treatment and follow-up, there were no statistical significance in the incidence of adverse reactions of two groups （P〉0.05） .In addition, up to December 31, 2016, the median survival of the observation group was significantly better than that of the control group, the difference was statistical significance （ P〈0.05 ） .Conclusion： The intensity modulated radiotherapy combined with TC chemotherapy can effectively improve the quality of life in patients with high risk endometrial cancer.

关 键 词：高危 子宫内膜癌 术后 调强放疗 TC化疗 

分 类 号：R737.33[医药卫生—肿瘤]