上皮-肌上皮癌的临床特点与疗效分析  

A retrospective study of the treatment for epithelial-myoepithelial carcinoma

作　　者：张江鹄[1] 黄晓东[1] 高黎[1] 易俊林[1] 杨琳[1] 马沛卿[1] 徐国镇[1] 罗京伟[1] 肖建平[1] 王凯[1] 曲媛[1] 张世平[1] 

机构地区：[1]国家癌症中心/中国医学科学院北京协和医学院肿瘤医院放疗科,北京100021

出　　处：《中华放射肿瘤学杂志》2017年第5期513-516,共4页Chinese Journal of Radiation Oncology

基　　金：国家重大研发计划项目（2016YFC0904600）

摘　　要：目的 分析上皮-肌上皮癌患者局部区域复发风险和长期生存的相关因素.方法 回顾分析1999-2015年收治的18例首程治疗或首程辅助治疗于本中心完成的上皮-肌上皮癌患者生存情况.单纯手术8例（44%）,术后辅助放疗9例（50%）,根治性同步放化疗1例（6%）.比较各组局部区域复发率和生存率.Kaplan-Meier法计算生存率,logrank法检验.结果 中位随访时间46个月,全组5例（27.8%）患者LRR,5年LRFS率为69%,5年OS率为93%.辅助放疗组5年LRFS优于单纯手术组,但未达统计学差异（71%∶57%,P=0.569）.结论 局部区域失败是上皮-肌上皮癌治疗的主要失败模式,进一步提高LC率是改进生存的关键.Objective To evaluate the risk of locoregional recurrence （LRR） and the influencing factors for long-term survival in patients with epithelial-myoepithelial carcinoma （EMCa）.Methods A retrospective analysis was performed for 18 EMCa patients, who received initial therapy or initial adjuvant therapy in our hospital from 1999 to 2015, to investigate their survival.Among these patients, 8（44%） underwent surgery alone, 9（50%） received adjuvant radiotherapy, and 1（6%） received radical concurrent chemoradiotherapy.Locoregional recurrence-free survival （LRFS） and overall survival （OS） rates were compared between these groups.The Kaplan-Meier mtthod was used to calculated survival rates and log-rank test was used to compare the LRFS.Results With a median follow-up time of 46 months, 5 patients developed LRR, and the 5-year LRFS and OS rates were 69% and 93%, respectively.The patients treated with radiotherapy had a significantly higher 5-year LRRFS rate than those not treated with radiotherapy （71% vs.57%, P=0.569）.Conclusions LRR is the main failure mode of EMCa treatment, and further improving local control is the key to improved survival.

关 键 词：头颈肿瘤/外科学 头颈肿瘤/放射疗法 上皮-肌上皮癌 

分 类 号：R739.8[医药卫生—肿瘤]