基于Ki-67对垂体瘤的预后评价  

Prognosis Evaluation on Pituitary Adenoma Based on Ki-67 Proliferation Index

作　　者：曹雪霞[1] 陈革[2] 王立[1] 穆志静[1] 孙丽娜[1] 修双玲[1] 马雅辉[1] 

机构地区：[1]首都医科大学宣武医院内分泌科,北京市100053 [2]首都医科大学宣武医院神经外科,北京市100053

出　　处：《中国病案》2017年第5期92-94,共3页Chinese Medical Record

摘　　要：目的本文根据Ki-67在垂体瘤中的表达,采用统计学工具,研究其在预后评价中的作用。方法根据影像资料获得垂体瘤的大小数据,依据每张切片上的阳性细胞表达百分数计算出Ki-67标记指数。分析复发组和未复发组间的Ki-67标记指数均值的差异,比较临床变量间的Ki-67标记指数的均值,探寻Ki-67标记指数和临床变量间的相关性。分析中采用了Mann-Whitney U检验和Fisher精确检验方法,以及受试者工作特征曲线等分析方法。所有统计计算及分析均在SPSS20.0统计软件上完成。结果 Ki-67标记指数与垂体瘤复发和侵袭性有关系。Ki-67标记指数阈值为3.45%,超过该阈值容易导致垂体瘤术后复发。结论 Ki-67标记指数的增高容易导致垂体瘤术后复发,降低预后效果。Ki-67标记指数对评价垂体瘤的手术预后是一项客观而准确的指标,对临床有一定的指导价值。Objectives According to the expression of Ki-67 in pituitary adenoma （PA）, to analyze its role in the prognosis evaluation with the application of statistics tools. Methods The data of PA size were obtained in terms of imaging diagnosis and Ki-67 labeling indexes （LI） were calculated according to the percentage of the positive cell expressions in the slides. The differences of Ki-67 LI between the group with recurrence and the group without recurrence were analyzed, the comparisons of Ki-67 LI among the clinical variables were conducted, and the correlations of other variables with recurrence arid Ki-67 LI were carried out. Mann-Whitney U test, receiver operating characteristic （ROC） curve analysis, and Fisher＇ s exact test were employed. Data and ROC analysis were performed with SPSS 20. 0. Results Ki-67 LI was related to recurrence of PA and the invasion of PA. Threshold value of the Ki-67 LI was 3.45%, which shows that recurrence of PA may occur if Ki-67 LI was larger than the value. Conclusions The increasing in Ki-67 LI may result in recurrence of PA and reduce the effectiveness of prognosis. Therefore, Ki-67 LI was considered as an objective and accurate index of prognosis of PA.

关 键 词：垂体瘤 KI-67 标记指数 预后 复发 

分 类 号：R736.4[医药卫生—肿瘤]