Treatment of exfoliative cheilitis with Traditional Chinese Medicine：a systematic review  

作　　者：Sun Kai Liu Lijun Chen Xiaojie Jiang Weiwen 

机构地区：[1]Department of Oral Mucosal Diseases, Shanghai Ninth People'sHospital, Shanghai Jiao Tong University School of Medicine,Shanghai 200011, China

出　　处：《Journal of Traditional Chinese Medicine》2017年第2期147-158,共12页中医杂志（英文版）

基　　金：Supported by National Natural Science Foundation of China(miRNA Expression Model During Oral Leukoplakia Cancerization,No.30872887);National Construction Project of Clinical Key Specialized Department[2013]544-03;Shanghai Natural Science Foundation(Epigenetic Regulation through GRIM19 Mediated Abnormal Metabolism in Head and Neck Carcinogenesis,No.15ZR1424700)

摘　　要：OBJECTIVE:To systematically review treatments of exfoliative cheilitis based on symptom patterns in terms of Traditional Chinese Medicine.METHODS:Pub Med, Cochrane Central Register of Controlled Trials and Wanfang data were screened for case reports, case series or clinical trials that were published in English or Chinese from January,1973 to September, 2015.The keyword of "exfoliative cheilitis or scaling cheilitis or factitious cheilitis" was used.Effectiveness or ineffectiveness was investigated as outcome for Meta analysis, which is based on effective index in each study.Response to treatment was described for case reports or case series.RESULTS:From 38 screened studies, 17 were randomized controlled trials(RCTs), 5 were single-arm trials, and 16 were case reports or case series.Three RCTs were eligible for Meta analysis and all of them compared managements between Traditional Chinese Medicine and corticosteroids for exfoliative cheilitis, which involved 223 participants.Interestingly, data of Meta analysis showed similar effect of Traditional Chinese Medicine and corticosteroids for patients with exfoliative cheilitis [relative risk ratio:1.10; 95% CI(1.00-1.21), P = 0.06].CONCLUSION:Traditional Chinese Medicine might be a substitute for corticosteroids on exfoliative cheilitis.However, the evidence and recommendation of exfoliative cheilitis managements need to be taken with caution because of the low quality of evidence in the studies obtained.OBJECTIVE：To systematically review treatments of exfoliative cheilitis based on symptom patterns in terms of Traditional Chinese Medicine.METHODS：Pub Med, Cochrane Central Register of Controlled Trials and Wanfang data were screened for case reports, case series or clinical trials that were published in English or Chinese from January,1973 to September, 2015.The keyword of ＂exfoliative cheilitis or scaling cheilitis or factitious cheilitis＂ was used.Effectiveness or ineffectiveness was investigated as outcome for Meta analysis, which is based on effective index in each study.Response to treatment was described for case reports or case series.RESULTS：From 38 screened studies, 17 were randomized controlled trials（RCTs）, 5 were single-arm trials, and 16 were case reports or case series.Three RCTs were eligible for Meta analysis and all of them compared managements between Traditional Chinese Medicine and corticosteroids for exfoliative cheilitis, which involved 223 participants.Interestingly, data of Meta analysis showed similar effect of Traditional Chinese Medicine and corticosteroids for patients with exfoliative cheilitis [relative risk ratio：1.10; 95% CI（1.00-1.21）, P = 0.06].CONCLUSION：Traditional Chinese Medicine might be a substitute for corticosteroids on exfoliative cheilitis.However, the evidence and recommendation of exfoliative cheilitis managements need to be taken with caution because of the low quality of evidence in the studies obtained.

关 键 词：Evidence-based medicine DENTISTRY Exfoliative syndrome CHEILITIS THERAPEUTICS Medicine Chinese traditional Adrenal cortex hormone Review 

分 类 号：R276.8[医药卫生—中医五官科学]