双岐杆菌四联活菌联合抗HP感染治疗消化性溃疡的疗效及预后的临床分析  

Clinical analysis of Bifidobacterium Tetravaccine combined with anti HP infection curative effect and prognosis in the treatment of peptic ulcer

作　　者：廖利春 

机构地区：[1]深圳市坪山新区妇幼保健院,广东深圳518122

出　　处：《疾病监测与控制》2017年第5期363-365,共3页Journal of Diseases Monitor and Control

摘　　要：目的探讨双岐杆菌四联活菌联合抗幽门螺杆菌(HP)感染治疗消化性溃疡的疗效及预后情况。方法选择2015年5月~2016年5月在我院就医的消化性溃疡或慢性胃炎患者共100例。随机分为观察组和对照组,各50人。对照组用奥美拉唑肠溶胶囊+阿莫西林胶囊+枸橼酸铋钾胶囊+左氧氟沙星胶囊。观察组加用双歧杆菌四联活菌片。随访6个月后,观察对比患者胃液PH值、HP根治情况、溃疡愈合情况,复发率及不良反应发生率。结果两组患者治疗后HP感染复发情况和不良反应发生情况均无太大差别,差异无统计学意义(P﹥0.05)。治疗后两组患者的PH值分别为(4.1±0.7)和(3.2±0.7);HP根除率分别为(70.0%)和(96.0%);对照组治愈溃疡16例、有效治疗30例、无效治疗10例,总体有效率为80%,观察组治愈溃疡35例、有效治疗13例、无效治疗2例,总体有效率为96%,两组间差异有统计学意义(P﹤0.05)。结论对于HP感染的消化性溃疡患者加用双岐杆菌四联活菌联合治疗后效果显著,值得临床推广。Objective Study of Bifidobacterium Tetravaccine combined with anti HP infection curative effect and prognosis in the treatment of peptic ulcer. Methods From May 2015 to May 2016, 100 patients with peptic ulcer or chronic gastritis who were hospitalized in our hospital were divided intoobservation group （50 cases） and control group （50 cases） randomly. The control group used Omeprazole Enteric-coated Capsules＋Amoxicillin Capsules＋Bismuth potassium Citrate Capsules＋Left Ofloxacin Capsules. The observation group was adding Bifidobacterium Tetravaccine tablets.After 6 months follow-up, the gastric juice pH value, HP radical status, ulcer healing, recurrence rate and incidence of adverse reactions were observed and compared. Results Two groups of patients after treatment of HP infection recurrence and adverse reactions were not much difference, the difference was not statistically significant （P 〉 0.05）. However, after treatment, the PH,the HP eradication rates for the control group and observation groups was respectively （4.1＋0.7） VS （3.2~0.7）, （70.0%） VS （96.0%）, the control group were cured 16 cases, effectiveness of 30 cases and failure of 10 cases with a total ameliorate rate of 80%. The observation group 35 cases of ulcer were cured,effectiveness of 13 cases and failure of 2 cases with a total ameliorate rate of 96%. The difference between the two groups was statistically significant （P 〈 0.05）. Conclusion bifidobacterium tetrabaccine tablets conbined treatment on peptic ulcer patients who infected with HP have a positive effect. It is worthy of clinical promotion.

关 键 词：双岐杆菌四联活菌 HP感染 消化性溃疡 预后 临床分析 

分 类 号：R573.1[医药卫生—消化系统]