CDK9与疾病相关研究进展  

Progress on the correlation of CDK9 with disease

作　　者：庞驰[1] 杜冠魁[1] 肖曼[1] 蔡望伟[1] 

机构地区：[1]海南医学院基础医学院,海口570102

出　　处：《生命的化学》2017年第2期212-216,共5页Chemistry of Life

摘　　要：细胞周期依赖性蛋白激酶9(cyclin-dependent kinases 9,CDK9)是丝氨酸/苏氨酸激酶家族成员之一,在细胞周期和凋亡中至关重要。CDK9是RNA转录关键延长因子,且通过磷酸化RNA聚合酶Ⅱ的羧基端结构域发挥功能。在这里我们概述了CDK9与炎症因子、流感病毒、艾滋病毒和肿瘤间的密切关系。我们通过对CDK9相关的途径的阐明,指出CDK9是细胞生物学的重要调节剂,CDK9途径的去调节可以为对人类疾病的发病机理和进展提供重要的见解。Cyclin-dependent kiaaase 9 （CDK9） is a member of the cdc2-1ike serine/threonine kinase family, CDK9 is crucial in the cell cycle and apoptosis. CDK9 is a key elongation factor for RNA transcription and functions by phosphorylating the C-terminal domain of RNA polymerase II. Herein we present an overview of the relationship between CDK9 with inflammatory cytokines, influenza virus, HIV and cancers. The eluci- dation of the CDK9-related pathway indicated that CDK9 is an important regulator of cell biology. Thus, the deregulations of CDK9 pathway may provide useful insights into the pathogenesis and progression of human disease.

关 键 词：CDK9 炎症细胞因子 流感病毒 艾滋病毒 肿瘤 

分 类 号：R363[医药卫生—病理学]