CT引导下经皮肺射频消融术治疗晚期肺癌的疗效及并发症分析  

Efficacy and complications of CT guided percutaneous lung radiofrequency ablation in patients with advanced lung cancer

作　　者：斯晓燕[1] 刘晓芳 王汉萍[1] 张晓彤[1] 李晓光[3] 张力[1] 

机构地区：[1]中国医学科学院北京协和医院呼吸内科,北京100730 [2]宁波市奉化区人民医院老年科,浙江宁波315500 [3]北京医院肿瘤微创治疗中心,北京100730

出　　处：《癌症进展》2017年第3期290-293,共4页Oncology Progress

摘　　要：目的评价CT引导下经皮肺射频消融治疗晚期肺癌的疗效和安全性,总结并发症情况及并发症的处理经验。方法回顾性分析29例接受CT引导下经皮肺射频消融术晚期肺癌患者的临床资料,评价疗效,总结并发症发生情况并分析并发症发生的诱因。结果 29例(共35个病灶)接受CT引导下经皮肺射频消融术晚期肺癌患者3、6个月局部控制率分别为77.1%、25.7%。16例患者在术中或术后出现并发症,其中疼痛5例(17.2%),发热5例(17.2%),咯血5例(17.2%),气胸5例(17.2%),皮下气肿3例(10.3%),感染3例(10.3%),纵隔气肿1例(3.4%),嗜睡1例(3.4%),窦性心动过缓1例(3.4%)。皮下气肿发生在消融病灶靠近胸膜的患者。无操作相关的死亡。结论对于多数晚期肺癌患者,CT引导下经皮肺射频消融术安全有效,并发症可防、可控。Objective To evaluate the efficacy and safety of CT guided percutaneous lung radiofrequency ablation （RFA） in advanced lung cancer patients, and to discuss the management of complications. Method Clinical data of 29 patients with advanced lung cancer who were treated with RFA were retrospectively analyzed, of which the incidence of complications and related risk factors were summarized. Result A total of 29 patients with 35 lung lesions were treated with RFA. The 3-month and 6-month local control rate were 77.1% and 25.7%, respectively. 16 patients experienced com- plications during or after procedures, including pain （5 cases, 17.2%）, fever （5 cases, 17.2%）, hemoptysis （5 cases, 17.2%）, pneumothorax （5 cases, 17.2%）, subcutaneous emphysema （3 cases, 10.3%）, infection （3 cases, 10.3%）, mediasti- hal emphysema （1 case, 3.4%）, somnolence （1 case, 3.4%） and sinus bradycardia （1 case, 3.4%）. Subcutaneous emphyse- ma occurred in patients with subpleural lesions. No report of procedure-related death. Conclusion CT guided percutane- ous RFA is effective and safe for most patients with advanced lung cancer, and complications are manageable.

关 键 词：肺癌 射频消融 并发症 

分 类 号：R734.2[医药卫生—肿瘤]