经典Wnt通路与肿瘤放射抗性关系的研究进展  

Research progress on the relationship between the canonical Wnt signaling pathway and tumor radiation resistance

作　　者：杨玉[1] 周欢娣[1] 薛晓英[1] 张歌[1] 韩雪涛[1] 

机构地区：[1]河北医科大学第二医院放疗科,石家庄050000

出　　处：《中华放射医学与防护杂志》2017年第4期316-320,共5页Chinese Journal of Radiological Medicine and Protection

基　　金：河北省自然科学基金（C2009001151）

摘　　要：放疗是治疗恶性肿瘤的重要手段,放射抗性是影响放疗疗效的重要因素,也是放疗失败的主要原因之一.近年来经典Wnt信号通路与肿瘤放射抗性的关系,逐渐受到学者的关注.本文检索了近10年来有关经典Wnt信号通路与肿瘤放射抗性的相关研究,并进行综述,对经典Wnt信号通路参与放射抗性形成的分子机制及功能进行系统分析和梳理,力求寻找某些规律和不同作用途径的内在联系,为进一步深入研究寻找有价值的线索.Radiotherapy is one of major cancer treatment methods.However,radiation resistance is an important reason to restrict the efficacy of radiotherapy and lead to treatment failure.In recent years,the relationship between the canonical Wnt signaling pathway and tumor radiation resistance has more and more attention of the scholars.This review summarized recent ten years findings concerning the canonical Wnt signaling pathway and tumor radiation resistance and tried to find some valuable rules or some internal relationships among different pathways by systemically analyzing.

关 键 词：经典Writ通路 肿瘤 放射抗性 

分 类 号：R730.55[医药卫生—肿瘤]