三阴型乳腺癌中CD47的表达及其临床意义  

Expression and clinical significance of CD47 in triple negative breast carcinoma

作　　者：张帆[1] 张伟[1] 焦南林[1] 刘霞[1] 曹明 徐国祥[1] 张伟璇[1] 

机构地区：[1]皖南医学院弋矶山医院临床病理科,芜湖241001 [2]芜湖市第一人民医院病理科,241000

出　　处：《临床与实验病理学杂志》2017年第5期539-543,共5页Chinese Journal of Clinical and Experimental Pathology

摘　　要：目的探讨CD47在三阴型乳腺癌(triple negative breast carcinoma,TNBC)中的表达及其与临床病理特征的相关性。方法运用组织芯片结合免疫组化Bond Polymer Refine Detection法对185例TNBC及35例非三阴型乳腺癌(non-triple negative breast carcinoma,NTNBC)进行染色,观察CD47在TNBC中的表达,分析其与各临床病理特征的关系。结果 TNBC肿瘤细胞CD47的表达均高于NTNBC,差异有统计学意义(P<0.05)。TNBC肿瘤细胞CD47阳性率为52.3%,与临床分期(P<0.05)、淋巴结转移/远处转移(P<0.05)和脉管侵犯(P<0.05)密切相关。结论 CD47表达与TNBC的临床分期、淋巴结转移/远处转移和脉管侵犯有相关性,可以作为预后评判指标,也是潜在的免疫治疗靶点。Purpose To explore the expression and clinical significance of CD47 in triple negative breast carcinoma （TN- BC）, and to analyze the relationship between CD47 expression and clinicopathologic features. Methods Immunohistochemical of Bond Polymer Refine Detection staining was performed on tissue array. It contains 185 cases of TNBC and 35 cases of non triple negative breast carcinoma （NTNBC）. Then we observed the expression of CD47 in TNBC, and analyzed the relationship between the expression of CD47 and various clinical pathological characteristics. Results The expression of CD47 in tumor ceils of TNBC was higher than that in NTNBC, and the difference was statistically significant （P 〈 0. 05 ）. The CD47 expression rate in TNBC tumors was 52. 3%. It was closely related to clinical stage （P 〈0. 05）, lymph node metastasis and distant metastasis （P 〈 0. 05 ） and vascular invasion （P 〈 0. 05 ）. Conclusion The expression of CI）47 is correlated with the clinical stage, lymph node metastasis, distant metastasis and vascular invasion of TNBC. CD47 can be used as a prognostic indicator and a potential target for immune therapy.

关 键 词：乳腺肿瘤 三阴型乳腺癌 CD47 免疫组织化学 靶向治疗 

分 类 号：R737.9[医药卫生—肿瘤]