脂氧素在炎症信号通路中的作用研究进展  

Recent progress of lipoxins in inflammatory signal pathway

作　　者：张沛[1] 彭洪军[1] 夏正坤[1] 

机构地区：[1]南方医科大学金陵医院(南京军区南京总医院)儿科,南京210002

出　　处：《中华实用儿科临床杂志》2017年第10期797-800,共4页Chinese Journal of Applied Clinical Pediatrics

基　　金：国家自然科学基金（81270800）;南京军区南京总医院自然科学基金（2016038）

摘　　要：脂氧素是一种花生四烯酸的代谢产物，能广泛调节多种炎性细胞的功能和炎症相关基因的表达，称为炎性反应的“停止信号（stop signals）”或“刹车信号（braking signals）”，脂氧素通过调控多种炎症信号通路促进炎症的消退。现对脂氧素调控多种炎症信号通路及其抗炎作用机制的研究进展进行综述。Lipoxins are metabolic products of arachidonic acid, which possess a wide spectrum of adjustment function for various inflammatory cell function and the expression of inflammatory related genes. It is known as ＂ stop signals＂ or ＂braking signals＂ of inflammatory response ,which can promote the regression of inflammation through regu- lating a variety of inflammatory signaling pathway. Now, the progress in the regulation of multiple signal pathways by li- poxius and its anti -inflammatory mechanism axe reviewed.

关 键 词：脂氧素 炎症 信号通路 

分 类 号：R364.5[医药卫生—病理学]