溶瘤腺病毒构建中可发展成为前列腺癌特异性启动子的生物分子  

Biological molecules found to serve as prostate cancer specific promoters during construction of oncolytic adenovirus

作　　者：蔡忠林[1] 周川[2] 庞捷[1] 花晨朝 周逢海[3] 

机构地区：[1]兰州大学第二医院泌尿外科,甘肃兰州730000 [2]四川大学华西医院泌尿外科,四川成都610041 [3]兰州军区兰州总医院泌尿外科,甘肃兰州730050

出　　处：《肿瘤》2017年第5期534-539,共6页Tumor

基　　金：兰州市人才创新创业项目(编号:2015-RC-16)~~

摘　　要：前列腺癌是一种在老年男性中高发的疾病,是男性癌症患者的第2大死因;在中国其发病率逐年上升,位居泌尿系统肿瘤发病率的第3位。携带特异性启动子的溶瘤腺病毒作为一种新型抗肿瘤方法,能够使病毒特异性地作用于肿瘤细胞并表达下游治疗基因,从而有效抑制肿瘤细胞生长,而对正常细胞不产生作用或者作用较小。目前,携带特异性启动子的溶瘤腺病毒已被研究者们广泛应用于基础研究及临床研究中,并显示出其独有的高效和安全优势。本文主要对溶瘤腺病毒构建时有望发展成为前列腺癌特异性启动子的多种生物分子进行综述。Prostate cancer is a common malignant disease in elder men, and it is the second leading death cause in male cancer patients. The incidence rate of prostate cancer has been increasing year by year, and it is ranked the third in the incidence rate of urologic cancers in China. The oncolytic adenovirus carrying specific promoter has been used as a novel target of antitumor therapy. The adenovirus has specific effects on tumor cells and can express downstream therapeutic genes to inhibit the growth of tumor cells, but it can＇t influence the normal cells or only has weak influence. At present, oncolytic adenovirus carrying specific promoter which has been used widely in basic and clinical studies has showed unique advantages in great antitumor effect and medication safety. This paper reviews the several biological molecules, which have been found during the construction of oncolytic adenovirus, may potentially become to be prostate cancer-specific promoters.

关 键 词：前列腺肿瘤 腺病毒 人 转录启动子 

分 类 号：R737.25[医药卫生—肿瘤]