对氧磷酶基因与阿尔茨海默病发病风险的Meta分析  

A comprehensive systematic review with meta-analysis on the relationship of the PON gene and Alzheimer's disease

作　　者：聂毅 罗丹阳 柳华[1,3,2] 刘伟[4] 熊利 龙继发 

机构地区：[1]西南医科大学临床医学院,成都621010 [2]南充市中心医院神经内科 [3]遂宁市中心医院神经中心 [4]南部县人民医院神经内科

出　　处：《中国神经精神疾病杂志》2017年第3期135-140,共6页Chinese Journal of Nervous and Mental Diseases

基　　金：四川省科技厅应用基础项目(编号:2015JY0122)

摘　　要：目的使用系统评价方法评估对氧磷酶(paraoxonase,PON)基因与阿尔茨海默病(Alzheimer's disease,AD)发病的相关性。方法检索中英文数据库以发现合格研究,使用纽卡斯尔-渥太华量表(Newcastle-Ottawa Scale,NOS)评价纳入研究质量,采用随机或固定效应模型计算合并比值比(odds ratio,OR),使用Q检验评估研究之间的异质性,失安全系数、Egger's检验和漏斗图评估发表偏倚。结果总共15项研究符合Meta分析纳入标准。所有研究NOS评分均为7分以上,纳入研究质量较高。共涉及4个位点,最多一个位点(PON1Q192R)涉及11项研究,累计病例2366例和对照2579例。结果显示,PON2 S311C多态性SS基因型降低了总人群AD发病风险(OR=0.82,95%CI:0.68~0.99,P=0.04)。没有发现其它遗传多态性与AD具有相关性。结论现有证据表明,PON2 S311C多态性与AD发病风险具有相关性,本结论亟待大样本重复研究进一步验证。Objective This study aimed to evaluate the association between the paraoxonase （PON） genes vari- ants and Alzheimer＇s disease （AD） using systematic review with recta-analysis. Methods Relevant studies were i- dentified by searching English and Chinese databases extensively. Newcastle-Ottawa Scale （NOS） was employed to e- valuate the quality of included studies. The odds ratio （OR） was calculated using a random-effects or fixed-effects model. A Q statistic was used to evaluate homogeneity, and fail-safe number, Egger＇s test and funnel plot were used to assess publication bias. Results A total of 15 studies were included and identified for the current recta-analysis. The NOS scores ranged from 7 to 8, meaning good quality of studies. It was found that the SS genotype of PON2 S311C polymorphism had an significant association with AD in the studied population （OR=0.82, P=0.04）. However, there was no significant relationship between other three genetic variants of PON genes and AD. Conclusions Exist- ing evidence indicated that the PON2 S311C polymorphism （SS genotype） was associated with risk of AD in studied population. Future studies with larger sample sizes will be necessary to confirm the present results.

关 键 词：对氧磷酶 阿尔茨海默病 系统评价 META分析 

分 类 号：R749.16[医药卫生—神经病学与精神病学]